A review on medicinally important heterocyclic compounds and importance of biophysical approach of underlying the insight mechanism in biological environment
Heterocyclic derivatives have more interesting biological properties which hold a
remarkable place in pharmaceutical industries due to their unique physiochemical …
remarkable place in pharmaceutical industries due to their unique physiochemical …
Exploring enzyme inhibition profiles of novel halogenated chalcone derivatives on some metabolic enzymes: Synthesis, characterization and molecular modeling …
Enzyme inhibition is a very active area of research in drug design and development.
Chalcone derivatives have a broad enzyme inhibitory activity and function as potential …
Chalcone derivatives have a broad enzyme inhibitory activity and function as potential …
[HTML][HTML] A biophysical approach of cytarabine anticancer drug insights into human serum albumin and checkpoint kinase 1
M Rupavarshini, S Karthikeyan, S Anandh… - Results in …, 2023 - Elsevier
The present studies used biophysical techniques to examine the binding interaction
mechanism of cytarabine anticancer drugs with human serum albumin (HSA) and …
mechanism of cytarabine anticancer drugs with human serum albumin (HSA) and …
A biophysical approach of tyrphostin AG879 binding information in: bovine serum albumin, human ErbB2, c-RAF1 kinase, SARS-CoV-2 main protease and …
S Karthikeyan, A Sundaramoorthy… - Journal of …, 2024 - Taylor & Francis
Viral infections cause significant health problems all over the world, and it is critical to
develop treatments for these problems. Antivirals that target viral genome-encoded proteins …
develop treatments for these problems. Antivirals that target viral genome-encoded proteins …
Insight into the binding mechanism of macrolide antibiotic; erythromycin to calf thymus DNA by multispectroscopic and computational approaches
N Shahabadi, M Razlansari - Journal of Biomolecular Structure and …, 2022 - Taylor & Francis
In the present study, the interactions between Erythromycin drug and calf thymus
deoxyribonucleic acid (ct-DNA) were explored by multi spectroscopic techniques (UV …
deoxyribonucleic acid (ct-DNA) were explored by multi spectroscopic techniques (UV …
Effects of human serum albumin glycation on the interaction with the tyrosine kinase inhibitor pazopanib unveiled by multi-spectroscopic and bioinformatic tools
Abstract Human Serum Albumin (HSA) is the most abundant plasma transport protein in the
human body. However, hyperglycemic conditions (as in diabetic patients) lead to glycated …
human body. However, hyperglycemic conditions (as in diabetic patients) lead to glycated …
Exploring conformational changes in β-lactoglobulin (β-LG) induced by silibinin: A comprehensive analysis of polyphenol-protein interaction
MS Khan, MT Rehman, M Arshad, S Karthikeyan… - Journal of Molecular …, 2025 - Elsevier
This study investigates the comprehensive characterization of the interaction between β-
lactoglobulin (β-LG) and Silibinin using various spectroscopic techniques. Fluorescence …
lactoglobulin (β-LG) and Silibinin using various spectroscopic techniques. Fluorescence …
Insights into the binding interaction mechanism of 12, 12-dihydrochromeno [2, 3-c] isoquinolin-5-amine in bovine serum albumin and prostaglandin H2 synthase-1: A …
The current study investigates the newly synthesized 12, 12-dihydrochromeno [2, 3-c]
isoquinolin-5-amine (drug) molecule binding interaction mechanism with bovine serum …
isoquinolin-5-amine (drug) molecule binding interaction mechanism with bovine serum …
Insights into the crystal structure and computational studies of newly synthesized thiazolopyrimidine derivatives against adenosine receptor (Thermostabilised …
SK Mohamed, Y El Bakri, AM Alfayomy… - Journal of Molecular …, 2023 - Elsevier
Efficient synthesis of biologically active molecules is one of the main objectives of organic
and medicinal chemistry. In this context, thiazolopyrimidine derivatives were synthesized in …
and medicinal chemistry. In this context, thiazolopyrimidine derivatives were synthesized in …
Time‐resolved emission spectroscopy to elucidate the functional nature of heat‐stable transcription factor
NHV Kutumbarao, S Karthikeyan… - Journal of Cellular …, 2022 - Wiley Online Library
A 22 kDa protein from Thermus thermophilus is characterised as a DNA binding
transcription regulator and its function is established using the fluorescence spectroscopy …
transcription regulator and its function is established using the fluorescence spectroscopy …