Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …

Conventional anticancer therapy using cytotoxic drugs lacks selectivity and is prone to
toxicity and drug resistance. Anticancer therapies targeting aberrant growth factor receptor …

The proteins within the human epidermal growth factor receptor (EGFR) family, members of
the tyrosine kinase receptor family, play a pivotal role in the molecular mechanisms driving …

In this paper the novel N-cycloalkyl-(cycloalkylaryl)-2-[(3-R-2-oxo-2H-[1, 2, 4] triazino [2, 3-c]
quinazoline-6-yl) thio] acetamides synthesis by aminolysis of activated by thionyl chloride or …

Multitarget agents have been increasingly explored for enhancing efficacy and reducing
countertarget activities and toxicities. Efficient virtual screening (VS) tools for searching …

The receptor tyrosine kinases (for example EGFR, PDGFR, VEGFR) are a transmembrane
protein family which plays a crucial role in tumor growth, survival, metastasis dissemination …

Overexpression of EGFR is responsible for causing a number of cancers, including lung
cancer as it activates various downstream signaling pathways. Thus, it is important to control …

According to the classical pharmacophore fusion strategy, a series of 6-arylureido-4-
anilinoquinazoline derivatives (Compounds 7a–t) were designed, synthesized, and …

Human African trypanosomiasis is caused by the eukaryotic microbe Trypanosoma brucei.
To discover new drugs against the disease, one may use drugs in the clinic for other …

A series of C-6 or C-3′ alkynyl-substituted 4-anilinoquinazoline derivatives was prepared
straightforwardly by a Sonogashira reaction of the corresponding bromo-substituted 4 …