Highlights•The generation of host-range mutants is usually not a limiting factor in
viruses.•Antagonistic pleiotropy partially limits the evolution of generalist viruses.•Epistasis …

Viral RNA dependent polymerases (vRdPs) are present in all RNA viruses; unfortunately,
their sequence similarity is too low for phylogenetic studies. Nevertheless, vRdP protein …

Understanding the evolutionary history of a virus and the mechanisms influencing the
direction of its evolution is essential for the development of more durable strategies to …

This study evaluates the extent to which genetic differences among host individuals from the
same species condition the evolution of a plant RNA virus. We performed a threefold …

The notion of fitness landscapes, a map between genotype and fitness, was proposed more
than 80 years ago. For most of this time data was only available for a few alleles, and thus …

A central question in protein molecular evolution is whether an amino acid that occurs at a
given site makes an independent contribution to fitness or whether its contribution depends …

Populations of plant RNA viruses are highly polymorphic in infected plants, which may allow
rapid within-host evolution. To understand tobacco etch potyvirus (TEV) evolution …

A critical issue to understanding how populations adapt to new selective pressures is the
relative contribution of the initial standing genetic diversity versus that generated de novo …

Recombination is an important driver in the evolution of viruses and thus is key to
understanding viral epidemics and improving strategies to prevent future outbreaks …

Bacteriophages are the most numerous biological entities on Earth. They are on the basis of
most ecosystems, regulating the diversity and abundance of bacterial populations and …