Tumour necrosis factor (TNF) is a classical, pleiotropic pro-inflammatory cytokine. It is also
the first 'adipokine'described to be produced from adipose tissue, regulated in obesity and …

Clinical studies have indicated the existence of an “obesity paradox” in patients with chronic
heart failure (HF), that is, reduced mortality in patients who have elevated body mass index …

Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

C-reactive protein, a hepatic acute phase protein largely regulated by circulating levels of
interleukin-6, predicts coronary heart disease incidence in healthy subjects. We have shown …

Obesity is highly associated with insulin resistance and is the biggest risk factor for non-
insulin-dependent diabetes mellitus,,. The molecular basis of this common syndrome …

The role of adipose tissue (AT) inflammation in obesity and its multiple related-complications
is a rapidly expanding area of scientific interest. Within the last 30 years, the role of the …

Cytokines appear to be major regulators of adipose tissue metabolism. Therapeutic
modulation of cytokine systems offers the possibility of major changes in adipose tissue …

The ability to ensure continous availability of energy despite highly variable supplies in the
environment is a major determinant of the survival of all species. In higher organisms …

Nearly 20 years ago, it was suggested that individuals exist who are not obese on the basis
of height and weight, but who, like people with overt obesity, are hyperinsulinemic, insulin …

Dyslipidemia and insulin resistance are commonly associated with catabolic or
lipodystrophic conditions (such as cancer and sepsis) and with pathological states of …