Effects and mechanisms of kaempferol in the management of cancers through modulation of inflammation and signal transduction pathways

A Almatroudi, KS Allemailem, WM Alwanian… - International Journal of …, 2023 - mdpi.com
Cancer is the principal cause of death and its incidence is increasing continuously
worldwide. Various treatment approaches are in practice to treat cancer, but these treatment …

Therapeutic importance of kaempferol in the treatment of cancer through the modulation of cell signalling pathways

MY Qattan, MI Khan, SH Alharbi, AK Verma… - Molecules, 2022 - mdpi.com
Plant-derived flavonoids are considered natural nontoxic chemo-preventers and have been
widely studied for cancer treatment in recent decades. Mostly all flavonoid compounds show …

Kaempferol and atherosclerosis: From mechanism to medicine

M Chen, J Xiao, HR El-Seedi, KS Woźniak… - Critical Reviews in …, 2024 - Taylor & Francis
Natural products possess pleiotropic cardiovascular protective effects owing to their anti-
oxidation, anti-inflammation and anti-thrombotic properties. Kaempferol,(3, 5, 7-trihydroxy-2 …

Network pharmacology analysis and experimental validation of kaempferol in the treatment of ischemic stroke by inhibiting apoptosis and regulating …

SS Zhang, M Liu, DN Liu, YF Shang, GH Du… - International Journal of …, 2022 - mdpi.com
Kaempferol, a natural plant flavonoid compound, has a neuroprotective effect on ischemic
stroke, while the specific mechanism remains unclear. In the current study, we applied the …

Isoliquiritigenin exerts antioxidative and anti-inflammatory effects via activating the KEAP-1/Nrf2 pathway and inhibiting the NF-κB and NLRP3 pathways in …

Y Gao, X Lv, H Yang, L Peng, X Ci - Food & function, 2020 - pubs.rsc.org
Pleurisy refers to a pleural disease caused by pathogenic factors that stimulate the pleura
associated with pleural inflammation and oxidative stress. Isoliquiritigenin (ISL), a flavonoid …

Anti-inflammatory activity of novel thiosemicarbazone compounds indole-based as COX inhibitors

ÍTT Jacob, FOS Gomes, MDS de Miranda… - Pharmacological …, 2021 - Springer
Background In this article, a series of 20 new thiosemicarbazone derivatives containing
indole were synthesized and evaluated for their anti-inflammatory potential. Methods The …

Evaluation of anti-inflammatory activity of Justicia secunda Vahl leaf extract using in vitro and in vivo inflammation models

GN Anyasor, AA Okanlawon, B Ogunbiyi - Clinical Phytoscience, 2019 - Springer
Abstract Background Justicia secunda Vahl. is a medicinal plant used in ethnomedical
practice as therapy to manage inflammation. Therefore, this study was designed to evaluate …

Modulation of cell signaling pathways by Phyllanthus amarus and its major constituents: potential role in the prevention and treatment of inflammation and cancer

H Harikrishnan, I Jantan, A Alagan, MA Haque - Inflammopharmacology, 2020 - Springer
The causal and functional connection between inflammation and cancer has become a
subject of much research interest. Modulation of cell signaling pathways, such as those …

Phytochemicals targeting JAK/STAT pathway in the treatment of rheumatoid arthritis: Is there a future?

G Kour, R Choudhary, S Anjum, A Bhagat… - Biochemical …, 2022 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune disorder and the treatment involves the
use of traditional and biological disease modifying anti-rheumatic drugs (DMARDs). Recent …

Rape bee pollen alleviates dextran sulfate sodium (DSS)-induced colitis by neutralizing IL-1β and regulating the gut microbiota in mice

S Chen, H Zhao, N Cheng, W Cao - Food research international, 2019 - Elsevier
Colitis is a major chronic disease in today's society. Consumption of phenolic compounds
can protect against colitis. We examined the phenolic compounds of rape bee pollen extract …