Microbiome multi-omics network analysis: statistical considerations, limitations, and opportunities

D Jiang, CR Armour, C Hu, M Mei, C Tian… - Frontiers in …, 2019 - frontiersin.org
The advent of large-scale microbiome studies affords newfound analytical opportunities to
understand how these communities of microbes operate and relate to their environment …

[HTML][HTML] Gene set analysis of genome-wide association studies: methodological issues and perspectives

L Wang, P Jia, RD Wolfinger, X Chen, Z Zhao - Genomics, 2011 - Elsevier
Recent studies have demonstrated that gene set analysis, which tests disease association
with genetic variants in a group of functionally related genes, is a promising approach for …

Failing loudly: An empirical study of methods for detecting dataset shift

S Rabanser, S Günnemann… - Advances in Neural …, 2019 - proceedings.neurips.cc
We might hope that when faced with unexpected inputs, well-designed software systems
would fire off warnings. Machine learning (ML) systems, however, which depend strongly on …

Evaluating the evaluation of cancer driver genes

CJ Tokheim, N Papadopoulos… - Proceedings of the …, 2016 - National Acad Sciences
Sequencing has identified millions of somatic mutations in human cancers, but
distinguishing cancer driver genes remains a major challenge. Numerous methods have …

Cognitive Chatbot for personalised contextual customer service: Behind the scene and beyond the hype

RK Behera, PK Bala, A Ray - Information Systems Frontiers, 2024 - Springer
With the proliferation of the use of chatbots across industries, business-to-business (B2B)
businesses have started using cognitive chatbots for improved customer service which …

Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension

X Zhu, T Feng, BO Tayo, J Liang, JH Young… - The American Journal of …, 2015 - cell.com
Genome-wide association studies (GWASs) have identified many genetic variants
underlying complex traits. Many detected genetic loci harbor variants that associate with …

A groupwise association test for rare mutations using a weighted sum statistic

BE Madsen, SR Browning - PLoS genetics, 2009 - journals.plos.org
Resequencing is an emerging tool for identification of rare disease-associated mutations.
Rare mutations are difficult to tag with SNP genotyping, as genotyping studies are designed …

Arguments for rejecting the sequential Bonferroni in ecological studies

MD Moran - Oikos, 2003 - JSTOR
Interpretation of results that include multiple statistical tests has been an issue of great
concern for some time in the ecological literature. The basic problem is that when multiple …

Non‐parametric combination and related permutation tests for neuroimaging

AM Winkler, MA Webster, JC Brooks… - Human brain …, 2016 - Wiley Online Library
In this work, we show how permutation methods can be applied to combination analyses
such as those that include multiple imaging modalities, multiple data acquisitions of the …

Comb-p: software for combining, analyzing, grouping and correcting spatially correlated P-values

BS Pedersen, DA Schwartz, IV Yang… - Bioinformatics, 2012 - academic.oup.com
comb-p is a command-line tool and a python library that manipulates BED files of possibly
irregularly spaced P-values and (1) calculates auto-correlation,(2) combines adjacent P …