Recent studies have demonstrated that gene set analysis, which tests disease association with genetic variants in a group of functionally related genes, is a promising approach for …
We might hope that when faced with unexpected inputs, well-designed software systems would fire off warnings. Machine learning (ML) systems, however, which depend strongly on …
CJ Tokheim, N Papadopoulos… - Proceedings of the …, 2016 - National Acad Sciences
Sequencing has identified millions of somatic mutations in human cancers, but distinguishing cancer driver genes remains a major challenge. Numerous methods have …
With the proliferation of the use of chatbots across industries, business-to-business (B2B) businesses have started using cognitive chatbots for improved customer service which …
Genome-wide association studies (GWASs) have identified many genetic variants underlying complex traits. Many detected genetic loci harbor variants that associate with …
BE Madsen, SR Browning - PLoS genetics, 2009 - journals.plos.org
Resequencing is an emerging tool for identification of rare disease-associated mutations. Rare mutations are difficult to tag with SNP genotyping, as genotyping studies are designed …
Interpretation of results that include multiple statistical tests has been an issue of great concern for some time in the ecological literature. The basic problem is that when multiple …
AM Winkler, MA Webster, JC Brooks… - Human brain …, 2016 - Wiley Online Library
In this work, we show how permutation methods can be applied to combination analyses such as those that include multiple imaging modalities, multiple data acquisitions of the …
comb-p is a command-line tool and a python library that manipulates BED files of possibly irregularly spaced P-values and (1) calculates auto-correlation,(2) combines adjacent P …