The development of new therapeutic approaches to diseases relies on the identification of
key molecular targets involved in amplifying disease processes. One such molecule is …

Diabetic retinopathy (DR), a leading cause of vision loss and blindness worldwide, is
caused by retinal neurovascular unit dysfunction, and its cellular pathology involves at least …

Defective autophagy occurred in osteoblasts under stress induced by high glucose and
played an essential role in the development of diabetic osteoporosis. Timosaponin BII, a …

Background Diabetic retinopathy (DR) signifies a frequent serious diabetic complication
influencing retinal structure and function. Dysregulation of lncRNAs drives a wide array of …

Currently, the incidence of metabolic disorders is increasing, setting a challenge to global
health. With major advancement in the diagnostic tools and clinical procedures, much has …

Astaxanthin has been reported to possess anti-inflammatory effect but the exact mechanism
in protecting the retinal pigment epithelial (RPE) cells is not clear. Hence, we hypothesized …

This research aim was to assess the impact of the seed extracts of the date cultivars (Qatara,
Barhi, and Ruthana) on rat's liver steatosis, oxidative stress, and inflammation triggered by …

Objective Diabetic retinopathy (DR) is a common diabetic microvascular complication and a
major cause of acquired vision loss. Finding effective biomarkers for the early identification …

Background Proliferative diabetic retinopathy (PDR) is a severe complication of diabetes,
and understanding its molecular mechanisms is crucial. Endoplasmic reticulum (ER) stress …

Dysfunction of the extraorbital lacrimal gland (ELG) can lead to loss of vision due to damage
to the epithelium of cornea. The broad-spectrum anti-epileptic drug sodium valproate (SV) …