Emerging Landscape of Mesenchymal Stem Cell Senescence Mechanisms and Implications on Therapeutic Strategies

J Wang, M Zhang, H Wang - ACS Pharmacology & Translational …, 2024 - ACS Publications
Mesenchymal stem cells (MSCs) hold significant promise for regenerative medicine and
tissue engineering due to their unique multipotent differentiation ability and …

Cellular microenvironment: a key for tuning mesenchymal stem cell senescence

W Sun, J Lv, S Guo, M Lv - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Mesenchymal stem cells (MSCs) possess the ability to self-renew and differentiate into
multiple cell types, making them highly suitable for use as seed cells in tissue engineering …

[HTML][HTML] Leptin deficiency impairs adipogenesis and browning response in mouse mesenchymal progenitors

K Velickovic, HAL Leija, B Kosic, H Sacks… - European journal of cell …, 2023 - Elsevier
Although phenotypically different, brown adipose tissue (BAT) and inguinal white adipose
tissue (iWAT) are able to produce heat through non-shivering thermogenesis due to the …

Identification of hub genes for early detection of bone metastasis in breast cancer

Z Zhao, H Yang, G Ji, S Su, Y Fan, M Wang… - Frontiers in …, 2022 - frontiersin.org
Background Globally, among all women, the most frequently detected and diagnosed and
the most lethal type of cancer is breast cancer (BC). In particular, bone is one of the most …

Elucidating the Mechanism of Large-Diameter Titanium Dioxide Nanotubes in Protecting Osteoblasts Under Oxidative Stress Environment: The Role of Fibronectin …

Y Xiang, D Lin, Q Zhou, H Luo, Z Zhou… - International Journal …, 2024 - Taylor & Francis
Background Large-diameter titanium dioxide nanotubes (TNTs) have shown promise in
preserving osteoblast function under oxidative stress (OS) in vitro. However, their ability to …

Integrated bioinformatics and experimental analysis identified TRIM28 a potential prognostic biomarker and correlated with immune infiltrates in liver hepatocellular …

J Han, Y Wang, H Zhou, S Ai… - … Mathematical Methods in …, 2022 - Wiley Online Library
Background. Since the 1970s, liver hepatocellular carcinoma (LIHC) has experienced a
constant rise in incidence and mortality rates, making the identification of LIHC biomarkers …

Screening for MicroRNA combination with engineered exosomes as a new tool against osteosarcoma in elderly patients

J Han, Z Zhao, Y Wang, T Yu, D Wan - Frontiers in Bioengineering …, 2022 - frontiersin.org
The most common primary malignant bone sarcoma is Osteogenic sarcoma (OS) which has
a bimodal age distribution. Unfortunately, the treatment of OS was less effective for elderly …

Pathological mechanisms and related markers of steroid-induced osteonecrosis of the femoral head

L Li, S Zhao, Z Leng, S Chen, Y Shi, L Shi, J Li… - Annals of …, 2024 - Taylor & Francis
Background Osteonecrosis of the femoral head (ONFH) is a refractory orthopedic disease
with a high disability rate. Long-term administration of steroids is the most common …

The underlying mechanisms of the association of bone health with depression–an experimental study

SP Houtenbos, Y He, P Cazzanelli, G Soultoukis… - Molecular Biology …, 2025 - Springer
Background Depression constitutes a risk factor for osteoporosis, but underlying molecular
and cellular mechanisms are not fully understood. MiRNAs influence gene expression and …

MiR-12200-5p targets multiple members of wnt signaling pathway to inhibit osteoblast differentiation and bone formation

H Li, C Yin, J Li, Q Huang, Y Huai, X Chu… - … Metabolic & Immune …, 2023 - ingentaconnect.com
Background: Osteoporosis is widespread and has become an emerging problem in the
elderly. MicroRNAs could affect osteoblast differentiation and further regulate the occurrence …