The inner ear is a very complex sensory organ whose development and function depend on
finely balanced interactions among diverse cell types. The many different kinds of inner ear …

Inherited diseases caused by connexin mutations are found in multiple organs and include
hereditary deafness, congenital cataract, congenital heart diseases, hereditary skin …

The human inner ear, which is segregated by a blood/labyrinth barrier, contains resident
macrophages [CD163, ionized calcium-binding adaptor molecule 1 (IBA1)-, and CD68 …

Background: The endolymphatic sac (ES) is endowed with a multitude of white blood cells
that may trap and process antigens that reach the inner ear from nearby infection-prone …

Connexins (Cxs) function as gap junction (GJ) channels and hemichannels that mediate
intercellular and transmembrane signaling, respectively. Here, we investigated the proximal …

Connexin 26 and connexin 30 are the prevailing isoforms in the epithelial and connective
tissue gap junction systems of the developing and mature cochlea. The most frequently …

Background Sensorineural hearing loss is one of the most common sensory deficiencies.
However, the molecular contribution to age-related hearing loss is not fully elucidated …

We have previously reported that young adult rats exposed to daily, short-duration noise for
extended time periods, develop accelerated presbycusis starting at 6 months of age …

Background: The cochlea produces an electric field potential essential for hair cell
transduction and hearing. This biological “battery” is situated in the lateral wall of the …

For monogenic genetic diseases, in utero gene therapy (IUGT) shows the potential for early
prevention against irreversible and lethal pathological changes. Moreover, animal models …