Exercise reduces the risk of a multitude of disorders, from metabolic disease to cancer, but
the molecular mechanisms mediating the protective effects of exercise are not completely …

Annexin-A1 (ANXA1) was first discovered in the early 1980's as a protein, which mediates
(some of the) anti-inflammatory effects of glucocorticoids. Subsequently, the role of ANXA1 …

Sustained nutrient (fuel) excess, as occurs during obesity and diabetes, has been linked to
increased inflammation, impaired mitochondrial homeostasis, lipotoxicity, and insulin …

Conventional approaches to identify secreted factors that regulate homeostasis are limited
in their abilities to identify the tissues/cells of origin and destination. We established a …

Due to its mass, skeletal muscle is the major site of glucose uptake and an important tissue
in the development of type 2 diabetes (T2D). Muscles of patients with T2D are affected with …

The vertebrate annexin superfamily (AnxA) consists of 12 members of a calcium (Ca2+) and
phospholipid binding protein family which share a high structural homology. In keeping with …

Objective Skeletal muscle is an important secretory organ, producing and releasing
numerous myokines, which may be involved in mediating beneficial health effects of …

Skeletal muscle is the largest tissues in the human body and is considered the primary
target for insulin-stimulated glucose disposal. In skeletal muscle, binding of the insulin to …

Homeostatic systems mount adaptive responses to meet the energy demands of the cell and
to compensate for dysfunction in cellular compartments. Such surveillance systems are also …

Aims Acute aortic dissection (AAD) is a life-threatening disease with high morbidity and
mortality. Previous studies have showed that vascular smooth muscle cell (VSMC) …