Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known
about its pathogenesis, and there is no specific or effective treatment. Its development …

Cancer-associated fibroblasts (CAF) are a poorly characterized cell population in the context
of liver cancer. Our study investigates CAF functions in intrahepatic cholangiocarcinoma …

Inflammation coordinates tissue regeneration via damaged cell removal and stem cell
activation. Hematopoietic stem cells (HSCs) survive inflammatory stress that kills other blood …

Regulatory T cells (Tregs) play a pivotal role in the inhibition of anti-tumor immune
responses. Understanding the mechanisms governing Treg homeostasis may therefore be …

Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

Exposure of articular cartilage to excessive mechanical loading is deeply involved in the
pathogenesis of osteoarthritis. Here, we identify gremlin-1 as a mechanical loading …

Physiological levels of Kras G12D are sufficient to induce pancreatic intraepithelial
neoplasias (PanINs); the mechanisms that drive PanIN progression are unknown. Here, we …

Although gastrointestinal cancers are frequently associated with chronic inflammation, the
underlying molecular links have not been comprehensively deciphered. Using loss-and gain …

Background & Aims One treatment strategy for pancreatic ductal adenocarcinoma is to
modify, rather than deplete, the tumor stroma. Constitutive activation of the signal transducer …