The activated product of the myc oncogene deregulates both cell growth and death check
points and, in a permissive environment, rapidly accelerates the affected clone through the …

Disruption of the physiologic balance between cell proliferation and death is a universal
feature of all cancers. In general terms, human B-cell lymphomas can be subdivided into 2 …

Background: MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that
have been shown to be aberrantly expressed in many human carcinomas. Of these miRNAs …

The cellular stress response pathway regulated by the p53 tumor suppressor is critical to the
maintenance of genomic integrity and to the prevention of oncogenic transformation …

MicroRNAs are naturally occurring small RNA species that regulate gene expression and
are frequently abnormally expressed in cancers. However, the role of microRNAs in …

Mantle-cell lymphoma (MCL) is a unique subtype of B-cell non-Hodgkin lymphoma (NHL)
that behaves aggressively and remains incurable. In order to understand the pathogenesis …

Mdm2 harnesses the p53 tumor suppressor, yet loss of one Mdm2 allele in Mdm2+/− mice
has heretofore not been shown to impair tumor development. Here we report that Mdm2 …

Diffuse large B‐cell lymphoma (DLBCL), the single largest category of lymphoma, is a
clinically and biologically heterogeneous disease entity. Clinically, patients differ in their …

ABSTRACT C-myc is an oncogene that functions both in the stimulation of cell proliferation
and in and apoptosis. C-myc elicits its oncogenic activity by causing immortalization, and to …

BACKGROUND Over‐expression of the oncogene c‐Myc has been implicated in the
development and progression of human prostate carcinoma. However, previous …