The basics of thiols and cysteines in redox biology and chemistry

LB Poole - Free Radical Biology and Medicine, 2015 - Elsevier
Cysteine is one of the least abundant amino acids, yet it is frequently found as a highly
conserved residue within functional (regulatory, catalytic, or binding) sites in proteins. It is …

Selenoproteins: molecular pathways and physiological roles

VM Labunskyy, DL Hatfield… - Physiological …, 2014 - journals.physiology.org
Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …

Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling

A Perkins, KJ Nelson, D Parsonage, LB Poole… - Trends in biochemical …, 2015 - cell.com
Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes
that play dominant roles in regulating peroxide levels within cells. These enzymes, often …

The role of oxidative stress in Parkinson's disease

V Dias, E Junn, MM Mouradian - Journal of Parkinson's …, 2013 - content.iospress.com
Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …

Photosynthesis-dependent H2O2 transfer from chloroplasts to nuclei provides a high-light signalling mechanism

M Exposito-Rodriguez, PP Laissue… - Nature …, 2017 - nature.com
Chloroplasts communicate information by signalling to nuclei during acclimation to
fluctuating light. Several potential operating signals originating from chloroplasts have been …

Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling

MC Sobotta, W Liou, S Stöcker, D Talwar… - Nature chemical …, 2015 - nature.com
Abstract Hydrogen peroxide (H 2 O 2) acts as a signaling messenger by oxidatively
modifying distinct cysteinyl thiols in distinct target proteins. However, it remains unclear how …

Selenium biochemistry and its role for human health

M Roman, P Jitaru, C Barbante - Metallomics, 2014 - academic.oup.com
Despite its very low level in humans, selenium plays an important and unique role among
the (semi) metal trace essential elements because it is the only one for which incorporation …

The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities

Z Huang, AH Rose, PR Hoffmann - Antioxidants & redox signaling, 2012 - liebertpub.com
Abstract Dietary selenium (] Se), mainly through its incorporation into selenoproteins, plays
an important role in inflammation and immunity. Adequate levels of Se are important for …

Hydrogen peroxide: its role in plant biology and crosstalk with signalling networks

M Černý, H Habánová, M Berka, M Luklová… - International journal of …, 2018 - mdpi.com
Hydrogen peroxide (H2O2) is steadily gaining more attention in the field of molecular
biology research. It is a major REDOX (reduction–oxidation reaction) metabolite and at high …

Oxidant sensing by reversible disulfide bond formation

CM Cremers, U Jakob - Journal of Biological Chemistry, 2013 - ASBMB
Maintenance of the cellular redox balance is crucial for cell survival. An increase in reactive
oxygen, nitrogen, or chlorine species can lead to oxidative stress conditions, potentially …