Chitosan-based hydrogels in cancer therapy: Drug and gene delivery, stimuli-responsive carriers, phototherapy and immunotherapy

H Zhu, H Sun, J Dai, J Hao, B Zhou - International journal of biological …, 2024 - Elsevier
Nanotechnology has transformed the oncology sector by particularly targeting cancer cells
and enhancing the efficacy of conventional therapies, not only improving efficacy of …

Lactic acid and hydroxyl terminated polybutadiene assisted synthesis of vegetable oil based polyurethanes for sustained drug delivery systems

A Iqbal, MA Javaid, U Tahir, MT Hussain, I Ullah… - Journal of Drug Delivery …, 2024 - Elsevier
The present research aims to develop a series of biodegradable, sustainable and
biocompatible, polyurethanes (PU–S1 to PU-S4). The synthesis of these polyurethanes …

Personalized nanovaccines for treating solid cancer metastases

T Feng, J Hu, J Wen, Z Qian, G Che, Q Zhou… - Journal of Hematology & …, 2024 - Springer
Cancer vaccines have garnered attention as a potential treatment for cancer metastases.
Nevertheless, the clinical response rate to vaccines remains< 30%. Nanoparticles stabilize …

Metformin‐Mediated Immunosuppressive Microenvironment Remodeling in Combination with Chemotherapy via a Spatial‐Specific Multi‐Responsive Carrier‐Free …

Y Song, Y Du, C Hu, L Lei, L Yang… - Advanced Functional …, 2024 - Wiley Online Library
The complex tumor immune pathology requires a precise spatial‐control release of the
combination drugs, but most multi‐drug loaded nanoparticles release all drugs …

Programmable Tetrahedral DNA‐RNA Nanocages Woven with Stimuli‐Responsive siRNA for Enhancing Therapeutic Efficacy of Multidrug‐Resistant Tumors

C Chen, M Yu, Q Li, Y Zhou, M Zhang, S Cai… - Advanced …, 2024 - Wiley Online Library
Multidrug resistance (MDR) is a major obstacle limiting the effectiveness of chemotherapy
against cancer. The combination strategy of chemotherapeutic agents and siRNA targeting …

MicroRNA‐Triggered Programmable DNA‐Encoded Pre‐PROTACs for Cell‐Selective and Controlled Protein Degradation

J Zhan, X Li, Z Feng, Z Liu, Z Feng… - Angewandte Chemie …, 2024 - Wiley Online Library
Proteolysis‐targeting chimeras (PROTACs) have accelerated drug development; however,
some challenges still exist owing to their lack of tumor selectivity and on‐demand protein …

Cascade Enzymes Confined in DNA Nanoanchors for Antitumor Therapy

D Wang, X Zhou, M Huang, J Duan, Y Qiu… - … Applied Materials & …, 2024 - ACS Publications
Cascade-enzyme reaction systems have emerged as promising tools for treating malignant
tumors by efficiently converting nutrients into toxic substances. However, the challenges of …

Self‐Adjuvanting Bacteria Hydrogel for SHP1 Checkpoint Inhibition in Tumor‐Draining Lymph Nodes to Enhance Cancer Immunotherapy

X Pan, F Liu, R Kang, Z Hu, Y Pang… - Advanced Functional …, 2024 - Wiley Online Library
Despite recent advances in immunotherapy, its efficacy remains constrained by the absence
of immune coordination. Especially, the interplay between tumor‐draining lymph nodes …

Nanotechnology-based in situ cancer vaccines: Mechanisms, design, and recent advances

G Niu, H Wang, Y Zhai, B Zhou, Y Kang, Z Pei, X Ji - Nano Today, 2024 - Elsevier
In recent years, in situ cancer vaccines, as an emerging cancer immunotherapy strategy,
have garnered considerable attention. This review comprehensively discusses the research …

A smart-responsive Y-shaped DNA scaffold drug conjugate achieving precise and synergetic tumor chemo-gene therapy via promoting tumor apoptosis and activating …

Y Wang, J Zhou, Y Dong, P Wang, R Zi, H Zhang… - Chemical Engineering …, 2024 - Elsevier
Constructing precise delivery systems to enhance the antitumor efficacy of drugs represents
a pressing clinical practice need. The characteristics of suitable physiological stability …