Host-directed antiviral therapy
Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …
components. However, this strategy often fails due to the rapid generation of drug-resistant …
Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases (CLKs) in human disease, an overview
MF Lindberg, L Meijer - International Journal of Molecular Sciences, 2021 - mdpi.com
Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …
Flavonoids as promising antiviral agents against SARS-CoV-2 infection: a mechanistic review
A newly diagnosed coronavirus in 2019 (COVID-19) has affected all human activities since
its discovery. Flavonoids commonly found in the human diet have attracted a lot of attention …
its discovery. Flavonoids commonly found in the human diet have attracted a lot of attention …
Viral-induced alternative splicing of host genes promotes influenza replication
MG Thompson, M Dittmar, MJ Mallory, P Bhat… - Elife, 2020 - elifesciences.org
Viral infection induces the expression of numerous host genes that impact the outcome of
infection. Here, we show that infection of human lung epithelial cells with influenza A virus …
infection. Here, we show that infection of human lung epithelial cells with influenza A virus …
Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells
Background Mounting evidence suggests that one of the ways that cells adapt to hypoxia is
through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia …
through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia …
An overview of cdc2‐like kinase 1 (Clk1) inhibitors and their therapeutic indications
Over the past decade, Clk1 has been identified as a promising target for the treatment of
various diseases, in which deregulated alternative splicing plays a role. First small …
various diseases, in which deregulated alternative splicing plays a role. First small …
Identification of chebulinic acid and chebulagic acid as novel influenza viral neuraminidase inhibitors
P Li, R Du, Y Wang, X Hou, L Wang, X Zhao… - Frontiers in …, 2020 - frontiersin.org
The influenza A virus (IAV) causes seasonal epidemics and occasional but devastating
pandemics, which are of a major public health concern. Although several antiviral drugs are …
pandemics, which are of a major public health concern. Although several antiviral drugs are …
CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer
Dysregulation of alternative splicing is a feature of cancer, both in aetiology and
progression. It occurs because of mutations in splice sites or sites that regulate splicing, or …
progression. It occurs because of mutations in splice sites or sites that regulate splicing, or …
Discovery of novel 5-methoxybenzothiophene hydrazides as metabolically stable Clk1 inhibitors with high potency and unprecedented Clk1 isoenzyme selectivity
Clk1 kinase is a key modulator of the pre-mRNA alternative splicing machinery which has
been proposed as a promising target for treatment of various tumour types, Duchenne's …
been proposed as a promising target for treatment of various tumour types, Duchenne's …
Advancements in host-based interventions for influenza treatment
TF Yip, ASM Selim, I Lian, SMY Lee - Frontiers in immunology, 2018 - frontiersin.org
Influenza is a major acute respiratory infection that causes mortality and morbidity
worldwide. Two classes of conventional antivirals, M2 ion channel blockers and …
worldwide. Two classes of conventional antivirals, M2 ion channel blockers and …