Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …

According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …

The role of NOD‐like receptor protein 3 (NLRP3)‐mediated pyroptosis in acute lung injury
(ALI) has been well identified previously. Stimulator of interferon genes (STING) is an …

Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …

Activation of the cGAS/STING innate immunity pathway is essential and effective for anti-
tumor immunotherapy. However, it remains largely elusive how tumor-intrinsic cGAS …

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

As a predominant type II protein arginine methyltransferase, PRMT5 plays critical roles in
various normal cellular processes by catalyzing the mono-and symmetrical dimethylation of …

Drug resistance remains a major challenge in cancer treatment, necessitating the
development of novel strategies to overcome it. Protein arginine methyltransferases …

Resistance of melanoma to targeted therapy and immunotherapy is linked to metabolic
rewiring. Here, we show that increased fatty acid oxidation (FAO) during prolonged BRAF …

ABSTRACT Protein arginine methyltransferase 5 (PRMT5) inhibitors are a new class of
antineoplastic agents showing promising preliminary clinical efficacy. Targeting an enzyme …