Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

Genetic and genomic studies, including genome-wide association studies (GWAS) have
accelerated the discovery of genes contributing to glaucoma, the leading cause of …

Paget's disease of bone (PDB) is a common disorder with a strong genetic component
characterized by focal increases in bone turnover, which in some cases is caused by …

The gut microbiota is a complex ecological community that plays multiple critical roles within
a host. Known intrinsic and extrinsic factors affect gut microbiota structure, but the influence …

Optineurin is a multifunctional adaptor protein intimately involved in various vesicular
trafficking pathways. Through interactions with an array of proteins, such as myosin VI …

Fast-replicating neurotropic herpesviruses exemplified by herpes simplex virus-1 (HSV-1)
naturally infect the central nervous system (CNS). However, most individuals intrinsically …

The exact mechanism of retinal ganglion cell loss in the pathogenesis of glaucoma is yet to
be understood. Mitochondrial damage‐associated molecular patterns (DAMPs) resulting …

Neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal
dementia, and glaucoma, affect millions of people worldwide. ALS is caused by the loss of …

Glaucoma is a degenerative disease of the eye. Both the anterior and posterior segments of
the eye are affected, extensive damage being detectable in the trabecular meshwork and …

Glaucoma is one of the leading causes of bilateral blindness affecting nearly 8 million
people worldwide. Glaucoma is characterized by a progressive loss of retinal ganglion cells …