Telomeres, oxidative stress, and timing for spontaneous term and preterm labor

M Phillippe - American Journal of Obstetrics and Gynecology, 2022 - Elsevier
Telomeres are nucleoprotein complexes located at the distal ends of chromosomes. In
adults, progressive telomere shortening occurs throughout the lifetime and is thought to …

Cell-free placental DNA: What do we really know?

N Yuen, M Lemaire, SL Wilson - PLoS genetics, 2024 - journals.plos.org
Cell-free placental DNA (cfpDNA) is present in maternal circulation during gestation.
CfpDNA carries great potential as a research and clinical tool as it provides a means to …

Cell-free fetal DNA increases prior to labor at term and in a subset of preterm births

N Gomez-Lopez, R Romero, G Schwenkel… - Reproductive …, 2020 - Springer
Cell-free fetal DNA in the maternal circulation has been associated with the onset of labor at
term. Moreover, clinical studies have suggested that cell-free fetal DNA has value to predict …

The telomere gestational clock: increasing short telomeres at term in the mouse

M Phillippe, MR Sawyer, PK Edelson - American Journal of Obstetrics and …, 2019 - Elsevier
Background The biologic mechanism (s) regulating the length of gestation are currently
poorly understood. After peaking at the blastocyst stage, the average telomere lengths have …

Fetal DNA causes sex-specific inflammation from human fetal membranes

CA Saito Reis, PK Ng, CK Kurashima, J Padron… - Frontiers in …, 2022 - frontiersin.org
Inflammation is central to the mechanisms of parturition, but the lack of understanding of how
it is controlled in normal parturition hampers our ability to understand how it may diverge …