Dysregulated ribosome quality control in human diseases

T McGirr, O Onar, SM Jafarnejad - The FEBS Journal, 2024 - Wiley Online Library
Precise regulation of mRNA translation is of fundamental importance for maintaining
homeostasis. Conversely, dysregulated general or transcript‐specific translation, as well as …

Interactions of amyloidogenic proteins with mitochondrial protein import machinery in aging-related neurodegenerative diseases

AL Reed, W Mitchell, AT Alexandrescu… - Frontiers in …, 2023 - frontiersin.org
Most mitochondrial proteins are targeted to the organelle by N-terminal mitochondrial
targeting sequences (MTSs, or “presequences”) that are recognized by the import machinery …

[HTML][HTML] Mitochondrial dynamics during development

L He, KJ Tronstad, A Maheshwari - Newborn (Clarksville, Md.), 2023 - ncbi.nlm.nih.gov
Mitochondria are dynamic membrane-bound organelles in eukaryotic cells. These are
important for the generation of chemical energy needed to power various cellular functions …

Rv0547c, a functional oxidoreductase, supports Mycobacterium tuberculosis persistence by reprogramming host mitochondrial fatty acid metabolism

J Medikonda, N Wankar, S Asalla, SO Raja… - Mitochondrion, 2024 - Elsevier
Mycobacterium tuberculosis (Mtb) successfully thrives in the host by adjusting its metabolism
and manipulating the host environment. In this study, we investigated the role of Rv0547c, a …

Mitochondria in early life

L He, A Maheshwari - Current Pediatric Reviews, 2023 - ingentaconnect.com
Mitochondria are highly-dynamic, membrane-bound organelles that generate most of the
chemical energy needed to power the biochemical reactions in eukaryotic cells. These …

The role of mitochondrial RNA association for mitochondrial homeostasis in neurons

I Segura, A Harbauer - Biochemical Journal, 2024 - portlandpress.com
The sub-compartmentalization of cellular processes is especially important in highly
polarized cells such as neurons, as their function rely on their complex morphology. The …

[HTML][HTML] Functional similarities and differences among subunits of the nascent polypeptide-associated complex (NAC) of Saccharomyces cerevisiae

BA Schilke, T Ziegelhoffer, P Domanski… - Cell Stress and …, 2024 - Elsevier
Protein factors bind ribosomes near the tunnel exit, facilitating protein trafficking and folding.
In eukaryotes, the heterodimeric nascent polypeptide-associated complex (NAC) is the most …

[HTML][HTML] Membrane-associated mRNAs: a post-transcriptional pathway for fine-turning gene expression

S Chen, MA Collart - Journal of Molecular Biology, 2024 - Elsevier
Gene expression is a fundamental and highly regulated process involving a series of tightly
coordinated steps, including transcription, post-transcriptional processing, translation, and …

Screening clusters of charged residues in plants' mitochondrial proteins and biological significance

S Nebli, A Rebai, I Ayadi - Mitochondrion, 2024 - Elsevier
Protein function is dependent on charge interactions and charge biased regions, which are
involved in a wide range of cellular and biochemical processes. We report the development …

Découverte du rôle crucial du résidu en position 2 des séquences MTS d'adressage mitochondrial

H El Barbry - 2023 - theses.hal.science
Les mitochondries sont des organites complexes impliquant un millier de protéines, la
plupart codées dans le génome nucléaire. Leur biogenèse a nécessité au cours de …