Since their discovery 20 years ago, miRNAs have attracted much attention from all areas of
biology. These short (∼ 22 nt) non-coding RNA molecules are highly conserved in evolution …

Gene expression universally relies on protein synthesis, where ribosomes recognize and
decode the messenger RNA template by cycling through translation initiation, elongation …

Background Growing evidences have been revealing that long noncoding RNAs are vital
factors in oncogenesis and tumor development. Among them, cancer susceptibility …

The ALYREF protein acts as a crucial epigenetic regulator in several cancers. However, the
specific expression levels and functional roles of ALYREF in cancers are largely unknown …

Triple-negative breast cancer (TNBC) is known as a highly aggressive subtype of BC due to
high rate of recurrence and metastasis, poor prognosis and lacking of effective targeted …

Non-coding RNA (ncRNA) comprises a substantial portion of primary transcripts that are
generated by genomic transcription, but are not translated into protein. The possible …

The translation inhibitor rocaglamide A (RocA) has shown promising antitumor activity
because it uniquely clamps eukaryotic initiation factor (eIF) 4A onto polypurine RNA for …

The dysregulation of mRNA translation is common in malignancies and may lead to
tumorigenesis and progression. Eukaryotic initiation factor 4A (eIF4A) proteins are essential …

The cap‐binding protein 4EHP/eIF4E2 has been a recent object of interest in the field of post‐
transcriptional gene regulation and translational control. From ribosome‐associated quality …

Background Regulation of the mRNA life cycle is central to gene expression control and
determination of cell fate. miRNAs represent a critical mRNA regulatory mechanism, but …