Airway remodeling is generally quite broadly defined as any change in composition,
distribution, thickness, mass or volume and/or number of structural components observed in …

Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

Inflammatory diseases have become increasingly prevalent with industrialization. To
address this, numerous anti-inflammatory agents and molecular targets have been …

▪ Abstract This review focuses on recent progress in our understanding of how mast cells
can contribute to the initiation, development, expression, and regulation of acquired immune …

While asthma is considered an inflammatory disorder of the conducting airways, it is
becoming increasingly apparent that the disease is heterogeneous with respect to …

Abstract Ossovskaya, Valeria S., and Nigel W. Bunnett. Protease-Activated Receptors:
Contribution to Physiology and Disease. Physiol Rev 84: 579–621, 2004; 10.1152/physrev …

Mast cells are important components of the immune system, and they perform pro-
inflammatory as well as anti-inflammatory roles in the complex process of immune regulation …

There is compelling evidence that human mast cells contribute to the pathophysiology of
asthma. Mast cells, but not T cells or eosinophils, localize within the bronchial smooth …

In addition to their role in protein degradation and digestion, proteases can also function as
hormone-like signaling molecules that regulate vital patho-physiological processes …

Serine proteinases such as thrombin, mast cell tryptase, trypsin, or cathepsin G, for example,
are highly active mediators with diverse biological activities. So far, proteinases have been …