In vertebrates, the skeletal muscles of the body and their associated stem cells originate
from muscle progenitor cells, during development. The specification of the muscles of the …

For decades, limb development has been a paradigm of three-dimensional patterning.
Moreover, as the limb muscles and the other tissues of the limb's musculoskeletal system …

Muscle precursors need to be correctly positioned during embryonic development for proper
body movement. In zebrafish, a subset of hypaxial muscle precursors from the anterior …

Genome-wide association studies have identified many susceptibility genes for adolescent
idiopathic scoliosis (AIS). However, most of the results are hard to be replicated in multi …

BACKGROUND CONTEXT Adolescent idiopathic scoliosis (AIS) is the leading cause of
spinal deformity in adolescents globally. Recent evidence from genome-wide association …

Idiopathic scoliosis (IS) is a structural lateral spinal curvature of≥ 10° that affects up to 3% of
otherwise healthy children and can lead to life-long problems in severe cases. It is well …

Study Design. A prospective case-control study. Objectives. To investigate whether the
asymmetric changes are primary or secondary to spinal deformity. Summary of Background …

Abstract Adolescent Idiopathic Scoliosis (AIS) is the most common type of spine deformity
affecting 2–3% of the population worldwide. The etiology of this disease is still poorly …

Abstract Fibroblast growth factor 8 (FGF8), a secreted signaling molecule, involves in
regulating cell survival, proliferation, migration, and differentiation. It exhibits a highly …

LBX1 is a gene located near a single‐nucleotide polymorphism, rs11190870, which is
highly associated with susceptibility to adolescent idiopathic scoliosis. However, the …