[HTML][HTML] Coronavirus biology and replication: implications for SARS-CoV-2

P V'kovski, A Kratzel, S Steiner, H Stalder… - Nature Reviews …, 2021 - nature.com
The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …

[HTML][HTML] The glycosylation in SARS-CoV-2 and its receptor ACE2

Y Gong, S Qin, L Dai, Z Tian - Signal Transduction and Targeted …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), a highly infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than …

Evolutionary constraint and innovation across hundreds of placental mammals

MJ Christmas, IM Kaplow, DP Genereux, MX Dong… - Science, 2023 - science.org
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

[HTML][HTML] ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities

N Zamorano Cuervo, N Grandvaux - elife, 2020 - elifesciences.org
Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with …

Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection

J Fantini, C Di Scala, H Chahinian, N Yahi - International journal of …, 2020 - Elsevier
The recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is
responsible for a worldwide pandemic. Given the global health emergency, drug …

Coronavirus membrane fusion mechanism offers a potential target for antiviral development

T Tang, M Bidon, JA Jaimes, GR Whittaker, S Daniel - Antiviral research, 2020 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the
need to develop effective therapies against the causative agent, SARS-CoV-2, and also …

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

S Bangaru, G Ozorowski, HL Turner, A Antanasijevic… - Science, 2020 - science.org
Vaccine efforts to combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), which is responsible for the current coronavirus disease 2019 (COVID-19) pandemic, are …

[HTML][HTML] Subunit vaccines against emerging pathogenic human coronaviruses

N Wang, J Shang, S Jiang, L Du - Frontiers in microbiology, 2020 - frontiersin.org
Seven coronaviruses (CoVs) have been isolated from humans so far. Among them, three
emerging pathogenic CoVs, including severe acute respiratory syndrome coronavirus …

[HTML][HTML] SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor

M Hoffmann, H Kleine-Weber, S Schroeder, N Krüger… - cell, 2020 - cell.com
The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in
China and its rapid national and international spread pose a global health emergency. Cell …

Structural insights into coronavirus entry

MA Tortorici, D Veesler - Advances in virus research, 2019 - Elsevier
Coronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the
beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS …