A fundamental question in cell biology, under investigation for over six decades, is the
structural organization of mitochondrial cristae. Long known to harbor electron transport …

Membrane biology seeks to understand how lipids and proteins within bilayers assemble
into large structures such as organelles and the plasma membranes. Historically, lipids were …

Among mitochondrial lipids, cardiolipin occupies a unique place. It is the only phospholipid
that is specific to mitochondria and although it is merely a minor component, accounting for …

Cardiolipin, the signature phospholipid of mitochondria, is a lipid dimer that is important for a
diverse range of mitochondrial activities beyond the process of ATP production. Thus not …

Cardiolipin is a unique phospholipid, which is almost exclusively localized in the
mitochondrial inner membrane where it is synthesized from phosphatidylglycerol and …

Mutations in the human TAZ gene are associated with Barth Syndrome, an often fatal X-
linked disorder that presents with cardiomyopathy and neutropenia. The TAZ gene encodes …

In this article, the formation of prokaryotic and eukaryotic cardiolipin is reviewed in light of its
biological function. I begin with a detailed account of the structure of cardiolipin, its …

Tafazzin is a putative enzyme that is involved in cardiolipin metabolism, it may carry
mutations responsible for Barth syndrome. To identify the biochemical reaction catalyzed by …

Cardiolipin is a unique mitochondrial phospholipid with an atypical fatty acid profile, but the
significance of its acyl specificity has not been understood. We explored the enormous …

Barth syndrome is an X-linked recessive disease caused by mutations in the tafazzin gene.
Patients have reduced concentration and altered composition of cardiolipin, the specific …