Cell types are the basic building blocks of multicellular organisms and are extensively
diversified in animals. Despite recent advances in characterizing cell types, classification …

Alternative splicing of mRNA precursors provides an important means of genetic control and
is a crucial step in the expression of most genes. Alternative splicing markedly affects human …

▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the …

In violation of the'one gene, one polypeptide'rule, alternative splicing allows individual
genes to produce multiple protein isoforms—thereby playing a central part in generating …

The precision and complexity of intron removal during pre-mRNA splicing still amazes even
26 years after the discovery that the coding information of metazoan genes is interrupted by …

Human genes contain a dense array of diverse cis-acting elements that make up a code
required for the expression of correctly spliced mRNAs. Alternative splicing generates a …

Troponin complex is a component of skeletal and cardiac muscle thin filaments. It consists of
three subunits—troponin I, T, and C, and it plays a crucial role in muscle activity, connecting …

The location of microRNAs (miRNAs) in cells determines their function in regulation activity.
Studies have shown that miRNAs are stable in the extracellular environment that mediates …

Abstract Myotonic dystrophy type 1 (DM1) is a dominant multisystemic disorder caused by a
CTG expansion in the 3′ untranslated region of the DMPK gene. A predominant …

The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein
involved in multiple aspects of messenger RNA metabolism, including the repression of …