Chronic kidney disease (CKD) is a complex and multifactorial disease, and one of the most
prevalent worldwide. Chronic kidney disease–mineral bone disorders (CKD–MBD) with …

The metabolically active and perpetually remodeling calcium phosphate–based
endoskeleton in terrestrial vertebrates sets the demands on whole-organism calcium and …

Extracellular phosphate regulates its own renal excretion by eliciting concentration-
dependent secretion of parathyroid hormone (PTH). However, the phosphate-sensing …

Background Disorders of mineral metabolism, including secondary hyperparathyroidism, are
thought to contribute to extraskeletal (including vascular) calcification among patients with …

Fast screening of enzyme variants is crucial for tailoring biocatalysts for the asymmetric
synthesis of non-natural chiral chemicals, such as amines. However, most existing …

Results Median parathyroid hormone increased from phase 1 to phase 4 in all regions
except for Japan, where it remained stable. Prescriptions of intravenous vitamin D analogs …

Allosteric ligands bind to G protein-coupled receptors (GPCRs; also known as seven-
transmembrane receptors) at sites that are distinct from the sites to which endogenous …

Background. This prospective, randomized, controlled trial compared the progression of
vascular and cardiac valve calcification in 360 prevalent adult hemodialysis patients with …

Background—Patients with kidney disease have disordered bone and mineral metabolism,
including elevated serum concentrations of fibroblast growth factor-23 (FGF23). These …

Chronic kidney disease (CKD) is a public health epidemic that affects millions of people
worldwide. Presence of CKD predisposes individuals to high risks of end-stage renal …