Heterotrimeric G protein signaling without GPCRs: The Gα-binding-and-activating motif
M Garcia-Marcos - Journal of Biological Chemistry, 2024 - ASBMB
Heterotrimeric G proteins (Gαβγ) are molecular switches that relay signals from 7-
transmembrane receptors located at the cell surface to the cytoplasm. The function of these …
transmembrane receptors located at the cell surface to the cytoplasm. The function of these …
A circuit for secretion‐coupled cellular autonomy in multicellular eukaryotic cells
Cancers represent complex autonomous systems, displaying self‐sufficiency in growth
signaling. Autonomous growth is fueled by a cancer cell's ability to “secrete‐and‐sense” …
signaling. Autonomous growth is fueled by a cancer cell's ability to “secrete‐and‐sense” …
Iridium (III) carbene complexes as potent girdin inhibitors against metastatic cancers
ML Ruan, WX Ni, JCH Chu, TL Lam… - Proceedings of the …, 2024 - National Acad Sciences
Many cancer-driving protein targets remain undruggable due to a lack of binding molecular
scaffolds. In this regard, octahedral metal complexes with unique and versatile three …
scaffolds. In this regard, octahedral metal complexes with unique and versatile three …
Growth signaling autonomy in circulating tumor cells aids metastatic seeding
Self-sufficiency (autonomy) in growth signaling, the earliest recognized hallmark of cancer,
is fueled by the tumor cell's ability to “secrete-and-sense” growth factors (GFs); this translates …
is fueled by the tumor cell's ability to “secrete-and-sense” growth factors (GFs); this translates …
Integrating inverse reinforcement learning into data-driven mechanistic computational models: a novel paradigm to decode cancer cell heterogeneity
Cellular heterogeneity is a ubiquitous aspect of biology and a major obstacle to successful
cancer treatment. Several techniques have emerged to quantify heterogeneity in live cells …
cancer treatment. Several techniques have emerged to quantify heterogeneity in live cells …
A Multiomic Analysis Reveals How Breast Cancers Disseminated to the Bone Marrow Acquire Aggressive Phenotypes through Tumor-Stroma Tunnels
Abstract Estrogen receptor-positive (ER+) breast cancer commonly disseminates to bone
marrow, where interactions with mesenchymal stromal cells (MSCs) shape disease …
marrow, where interactions with mesenchymal stromal cells (MSCs) shape disease …