Vitamin D is a hormone with both genomic and non-genomic actions. It exerts its activity by
binding vitamin D receptor (VDR), which belongs to the superfamily of nuclear receptors and …

Vitamin D is considered an essential micronutrient for human health that is metabolized into
a multifunctional secosteroid hormone. We can synthesize it in the skin through ultraviolet B …

Vitamin D is neccessary for regulation of calcium and phosphorus metabolism in bones,
affects imunity, the cardiovascular system, muscles, skin, epithelium, extracellular matrix, the …

Fanconi anaemia (FA) is the most frequent inherited bone marrow failure syndrome, due to
mutations in genes encoding proteins involved in replication fork protection, DNA interstrand …

Ageing is the biggest risk factor for the development of multiple chronic diseases as well as
increased infection susceptibility and severity of diseases such as influenza and COVID-19 …

The vitamin D receptor binds the seco-steroid hormone 1, 25 (OH) 2D3 with high affinity and
controls gene programs that include a significant component of the control of serum calcium …

Abstract Vitamin D Receptor (VDR), a nuclear steroid receptor, is a transcription factor with a
primary physiologic role in calcium metabolism. It has also a physiologic role in breast …

Mild traumatic brain injury (mTBI) leads to diverse symptoms including mood disorders,
cognitive decline, and behavioral changes. In some individuals, these symptoms become …

Cellular senescence response is (i) activated by numerous stresses,(ii) is characterized by a
stable proliferation arrest, and (iii) by a set of specific features. Timely regulated senescence …

Calcium signaling is emerging as a key pathway controlling cellular senescence, a stable
cell proliferation arrest playing a fundamental role in pathophysiological conditions, such as …