Introduction In recent years, molecular characterization of renal cell carcinoma has
facilitated the identification of driver genes, specific molecular pathways, and …

Purpose Clear cell, papillary cell, and chromophobe renal cell carcinomas (RCCs) have
now been well characterised thanks to large collaborative projects such as The Cancer …

Objectives To develop and validate a CT-based deep learning radiomics nomogram (DLRN)
for outcome prediction in clear cell renal cell carcinoma (ccRCC), and its performance was …

Clear cell renal cell carcinoma (ccRCC) is the most aggressive RCC subtype with high
metastasis, chemotherapy and radiotherapy resistance, and poor prognosis. This study …

Signal transduction through the transforming growth factor-beta 1 (TGF-β1) pathway affects
epithelial to mesenchymal transition (EMT), partly by modulation of E-Cadherin expression …

Simple Summary Intratumor heterogeneity (ITH) is a constant event in malignant tumors and
the cause of most therapeutic failures in modern oncology. Since clear cell renal cell …

The molecular characteristics of early-stage clear cell renal cell carcinomas (ccRCCs)
measuring≤ 7 cm associated with poor clinical outcomes remain poorly understood. Here …

Abstract Purpose of Review Intratumor heterogeneity is an inherent event in tumor
development that is receiving much attention in the last years since it is responsible for most …

Intertumor heterogeneity, defined as the spectrum of morphological differences found in
similar tumors in different patients, is a well‐known event for pathologists. However, recent …

Intratumor heterogeneity (ITH) is increasingly being recognized as a highly complex process
with high clinical impact that deserves special attention from practicing pathologists. The …