Extensive research on the Ras proteins and their functions in cell physiology over the past
30 years has led to numerous insights that have revealed the involvement of Ras not only in …

The search for genetic damage in neoplastic cells now occupies a central place in cancer
research. Diverse examples of such damage are in hand, and they in turn hint at …

The mammalian genome contains several hundred microRNAs that regulate gene
expression through modulation of target mRNAs. Here, we report a fragile chromosomal …

RNAse A mismatch cleavage analysis of 66 primary human colon tumours reveals a high
incidence of K-ras genes with mutations at position 12. No apparent correlation was found …

Cellular proto-oncogenes can be activated by both point mutations and chromosomal
translocations, suggesting that there may be a direct link between exposure to agents which …

The neu oncogene, which is frequently activated in neuro-and glloblastomas of BDIX rats,
was originally identified in the NIH 3T3 focus-forming assay. cDNA clones of the normal and …

UV radiation is a potent DNA damaging agent and a known inducer of skin cancer in
experimental animals. There is excellent scientific evidence to indicate that most non …

Induction of mammary carcinomas in rats by a single exposure to a carcinogen during
sexual development often involves malignant activation of the Ha-ras-1 locus. Each of the …

A series 11 gamma-ray-induced mutants at the dihydrofolate reductase (dhfr) locus in
Chinese hamster ovary cells has been examined for the types of DNA sequence change …

Publisher Summary This chapter discusses the advances made in understanding the
mechanisms of action of chemical carcinogens in the light of the recent evidence that …