Broadening the scope of biocatalysis in sustainable organic synthesis

RA Sheldon, D Brady - ChemSusChem, 2019 - Wiley Online Library
This Review is aimed at synthetic organic chemists who may be familiar with organometallic
catalysis but have no experience with biocatalysis, and seeks to provide an answer to the …

Same substrate, many reactions: oxygen activation in flavoenzymes

E Romero, JR Gómez Castellanos, G Gadda… - Chemical …, 2018 - ACS Publications
Over time, organisms have evolved strategies to cope with the abundance of dioxygen on
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …

[HTML][HTML] Flavoprotein monooxygenases: versatile biocatalysts

CE Paul, D Eggerichs, AH Westphal, D Tischler… - Biotechnology …, 2021 - Elsevier
Flavoprotein monooxygenases (FPMOs) are single-or two-component enzymes that
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …

Baeyer–Villiger monooxygenases: tunable oxidative biocatalysts

MJLJ Fürst, A Gran-Scheuch, FS Aalbers… - ACS …, 2019 - ACS Publications
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical
industry a poor public reputation, despite their undisputable importance to society …

Homogeneous oxygenase catalysis

Y Liang, J Wei, X Qiu, N Jiao - Chemical reviews, 2018 - ACS Publications
Oxygenases-catalyzed reductive activation of molecular oxygen and incorporation of O
atoms into an organic molecule is undoubtedly one of the most attractive research areas …

A coenzyme-free biocatalyst for the value-added utilization of lignin-derived aromatics

J Ni, YT Wu, F Tao, Y Peng, P Xu - Journal of the American …, 2018 - ACS Publications
Value-added utilization of lignin waste streams is vital to fully sustainable and economically
viable biorefineries. However, deriving substantial value from its main constituents is …

Batch and continuous flow asymmetric synthesis of anabolic-androgenic steroids via a single-cell biocatalytic Δ 1-dehydrogenation and C17β-carbonyl reduction …

Y Zhang, M Liu, Z Yang, J Lin, Z Huang, F Chen - Green Chemistry, 2023 - pubs.rsc.org
Chemoenzymatic asymmetric synthesis of an anabolic-androgenic steroid (+)-boldenone (3)
and its prodrug (+)-boldenone undecylenate (4) was accomplished starting from …

Hot spots for the protein engineering of Baeyer-Villiger monooxygenases

K Balke, A Beier, UT Bornscheuer - Biotechnology advances, 2018 - Elsevier
Abstract Baeyer-Villiger monooxygenases (BVMOs) are versatile biocatalysts for the
conversion of ketones to lactones or esters while also being able to efficiently oxidize …

A Baeyer-Villiger monooxygenase from Cupriavidus basilensis catalyzes asymmetric synthesis of (R)-lansoprazole and other pharmaco-sulfoxides

F Liu, C Shou, Q Geng, C Zhao, J Xu, H Yu - Applied Microbiology and …, 2021 - Springer
Biocatalytic synthesis of pharmaco-chiral sulfoxides has gained interest in recent years for
its environmental friendliness. However, only a few natural biocatalysts can be used for the …

Mutations Increasing Cofactor Affinity, Improve Stability and Activity of a Baeyer–Villiger Monooxygenase

HR Mansouri, O Gracia Carmona, J Jodlbauer… - ACS …, 2022 - ACS Publications
The typically low thermodynamic and kinetic stability of enzymes is a bottleneck for their
application in industrial synthesis. Baeyer–Villiger monooxygenases, which oxidize ketones …