Human contains 49 ATP-binding cassette (ABC) transporter genes and the multidrug
resistance associated proteins (MRP1/ABCC1, MRP2/ABCC2, MRP3/ABCC3 …

Resistance to chemotherapy is a critical issue in the management of breast cancer patients.
The nature of clinical drug resistance is likely to be multifactorial. However, in the last …

The efficacy of chemotherapy for malignant primary or metastatic brain tumours is still poor.
This is at least partly due to the presence of the blood-brain barrier (BBB). The functionality …

Permeability of the blood-brain barrier (BBB) is one of the factors determining the
bioavailability of therapeutic drugs. The BBB only allows entry of lipophilic compounds with …

With the realization of the importance of drug efflux transporters in disease processes and
treatment, development of inhibitors to these transporters has been sought for use as …

Coelenterazine is widely distributed among marine organisms, producing bioluminescence
by calcium-insensitive oxidation mediated by Renilla luciferase (Rluc) and calcium …

Over the past several decades, radionuclides have matured from largely esoteric and
experimental technologies to indispensible components of medical diagnostics. Driving this …

The purpose of this study was to identify the effects of dietary flavonoids, which are present
in fruits, vegetables, and plant-derived beverages, on the transport of daunomycin (DNM) …

Molecular imaging is broadly defined as the characterization and measurement of biological
processes in living animals, model systems, and humans at the cellular and molecular level …

Positron emission tomography (PET) scanning is evolving as a unique tool for drug
development in oncology for improving both the efficacy of established treatment and in …