Reactive oxygen species (ROS)-dependent production of ROS underlies sustained
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …

Cardiovascular disease is the leading cause of death in western countries. Among
cardiovascular diseases, myocardial infarction represents a life-threatening condition …

Cardiac remodelling is classified as physiological (in response to growth, exercise and
pregnancy) or pathological (in response to inflammation, ischaemia, ischaemia/reperfusion …

Mechanical properties are cues for many biological processes in health or disease. In the
heart, changes to the extracellular matrix composition and cross-linking result in stiffening of …

Calcific aortic valve disease (CAVD) is the end result of active cellular processes that lead to
the progressive fibrosis and calcification of aortic valve leaflets. In western populations …

New Findings What is the topic of this review? This review provides a comprehensive
overview of Nox5 from basic biology to human disease and highlights unique features of this …

Heart failure is a growing health burden worldwide characterized by alterations in excitation-
contraction coupling, cardiac energetic deficit and oxidative stress. While current treatments …

Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide. Despite
extensive efforts to provide early diagnosis and adequate treatment regimens, detection of …

This study sought to investigate whether reactive oxygen species (ROS)–generating
reduced nicotinamide adenine dinucleotide phosphate oxidase 2 (Nox2) contributes to …

The incidence of chronic aging‐associated diseases, especially cardiovascular and
prostatic diseases, is increasing with the aging of society. Evidence indicates that …