Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin …

C Mouffouk, S Mouffouk, S Mouffouk… - European journal of …, 2021 - Elsevier
The novel coronavirus outbreak (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) represents the actual greatest global public health crisis. The …

A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug Discovery

A Intharuksa, W Arunotayanun, W Yooin, P Sirisa-Ard - Molecules, 2022 - mdpi.com
The COVID-19 pandemic has intensively disrupted global health, economics, and well-
being. Andrographis paniculata (Burm. f.) Nees has been used as a complementary …

[HTML][HTML] Inhibition of the main protease of SARS-CoV-2 (Mpro) by repurposing/designing drug-like substances and utilizing nature's toolbox of bioactive compounds

I Antonopoulou, E Sapountzaki, U Rova… - Computational and …, 2022 - Elsevier
The emergence of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)
has resulted in a long pandemic, with numerous cases and victims worldwide and enormous …

Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2

K Gao, R Wang, J Chen, L Cheng, J Frishcosy… - Chemical …, 2022 - ACS Publications
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

After the hurricane: Anti-COVID-19 drugs development, molecular mechanisms of action and future perspectives

HO Khalifa, YM Al Ramahi - International Journal of Molecular Sciences, 2024 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a new coronavirus in
the Coronaviridae family. The COVID-19 pandemic, caused by SARS-CoV-2, has …

In silico identification of novel benzophenone–coumarin derivatives as SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitors

SM Patil, RM Martiz, R Ramu, PS Shirahatti… - Journal of …, 2022 - Taylor & Francis
In this study, we propose our novel benzophenone–coumarin derivatives (BCDs) as potent
inhibitors of the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 virus, one of the …

Ayurveda Rasayana as antivirals and immunomodulators: potential applications in COVID-19

R Singh, S Goel, P Bourgeade, L Aleya… - … Science and Pollution …, 2021 - Springer
Abstract Coronavirus disease (COVID-19) has been declared as a pandemic by the World
Health Organization with rapid spread across 216 countries. COVID-19 pandemic has left its …

Isoquercetin as an anti-covid-19 medication: A potential to realize

M Mbikay, M Chrétien - Frontiers in Pharmacology, 2022 - frontiersin.org
Isoquercetin and quercetin are secondary metabolites found in a variety of plants, including
edible ones. Isoquercetin is a monoglycosylated derivative of quercetin. When ingested …

An insight into the potent medicinal plant Phyllanthus amarus Schum. and Thonn.

A Bose Mazumdar Ghosh, A Banerjee… - The Nucleus, 2022 - Springer
Abstract Phyllanthus amarus Schum. and Thonn., a globally distributed herb is known for its
several therapeutic potentials. P. amarus has a long history of use in the traditional system of …

Molecular docking and in-silico analysis of natural biomolecules against dengue, ebola, zika, SARS-CoV-2 variants of concern and monkeypox virus

MK Dassanayake, TJ Khoo, CH Chong… - International Journal of …, 2022 - mdpi.com
The emergence and rapid evolution of human pathogenic viruses, combined with the
difficulties in developing effective vaccines, underline the need to develop innovative broad …