Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …

The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus,
drugs targeting cancer cell metabolism may have promising therapeutic potential. Previous …

Immunotherapies like the adoptive transfer of gene-engineered T cells and immune
checkpoint inhibitors are novel therapeutic modalities for advanced cancers. However, some …

Diabetes is accompanied by several complications. Higher prevalence of cancers,
cardiovascular diseases, chronic kidney disease (CKD), obesity, osteoporosis, and …

Stimulating antitumor immunity is an attractive idea for suppressing tumors. CD4+ and CD8+
T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor …

Cancer chemoprevention is the most effective approach to control cancer in the population.
Despite significant progress, chemoprevention has not been widely adopted because …

Simple Summary In the last two decades, the antidiabetic drugs, biguanides, have received
considerable interest owing to their presumed antitumor properties. A critical issue that has …

Cancer progression generates a chronic inflammatory state that dramatically influences
hematopoiesis, originating different subsets of immune cells that can exert pro-or anti-tumor …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that accumulate in tumor-bearing hosts to reduce T cells activity and promote …

Nonalcoholic fatty liver disease (NAFLD) is strongly linked to the global epidemic of obesity
and type 2 diabetes mellitus (T2DM). Notably, NAFLD can progress from the mildest form of …