Recent advances in enterotoxin vaccine adjuvants

JW Crothers, EB Norton - Current Opinion in Immunology, 2023 - Elsevier
Enterotoxin adjuvants have been researched for their ability to promote immunity to co-
delivered antigens. Outside of cholera vaccines, however, these proteins have yet to be …

Vibrio cholerae, classification, pathogenesis, immune response, and trends in vaccine development

DA Montero, RM Vidal, J Velasco, S George… - Frontiers in …, 2023 - frontiersin.org
Vibrio cholerae is the causative agent of cholera, a highly contagious diarrheal disease
affecting millions worldwide each year. Cholera is a major public health problem, primarily in …

A Polyvalent Adhesin–Toxoid Multiepitope-Fusion-Antigen-Induced Functional Antibodies against Five Enterotoxigenic Escherichia coli Adhesins (CS7, CS12, CS14 …

S Li, H Seo, I Upadhyay, W Zhang - Microorganisms, 2023 - mdpi.com
The increasing prevalence and association with moderate-to-severe diarrhea make
enterotoxigenic Escherichia coli (ETEC) adhesins CS7, CS12, CS14, CS17, and CS21 …

Polyvalent protein adhesin MEFA-II induces functional antibodies against enterotoxigenic Escherichia coli (ETEC) adhesins CS7, CS12, CS14, CS17, and CS21 and …

I Upadhyay, SMD Parvej, S Li, KL Lauder… - Applied and …, 2023 - Am Soc Microbiol
There are no licensed vaccines for enterotoxigenic Escherichia coli (ETEC), a common
cause of children's diarrhea and travelers' diarrhea. ETEC strains producing enterotoxins …

Protein-based vaccine candidate MecVax broadly protects against enterotoxigenic Escherichia coli intestinal colonization in a rabbit model

I Upadhyay, SMD Parvej, Y Shen, S Li… - Infection and …, 2023 - Am Soc Microbiol
There are no vaccines licensed against enterotoxigenic Escherichia coli (ETEC), a leading
cause of children's diarrhea and the most common cause of travelers' diarrhea. Multivalent …

Polyvalent passive vaccine candidates from egg yolk antibodies (IgY) of important outer membrane proteins (PF1380 and ExbB) of Pseudomonas fluorescens in fish

X Liu, H Xiao, J Chao, S Jian, X Wu, J Lu… - Fish & Shellfish …, 2023 - Elsevier
Polyvalent antibodies can resist multiple bacterial species, and immunoglobulin Y (IgY)
antibody can be economically prepared in large quantities from egg yolk; further, IgY …

Adjuvants for Helicobacter pylori vaccines: Outer membrane vesicles provide an alternative strategy

H Zhang, Z Liu, Y Li, Z Tao, L Shen, Y Shang, X Huang… - Virulence, 2024 - Taylor & Francis
Helicobacter pylori (H. pylori) is a gram-negative, spiral-shaped bacterium that colonizes the
human stomach, leading to various gastric diseases. The efficacy of traditional treatments …

MecVax supplemented with CFA MEFA-II induces functional antibodies against 12 adhesins (CFA/I, CS1–CS7, CS12, CS14, CS17, and CS21) and 2 toxins (STa, LT) …

C Zhang, S Li, I Upadhyay, KL Lauder… - Microbiology …, 2024 - Am Soc Microbiol
Enterotoxigenic Escherichia coli (ETEC) strains that produce various adhesins and one or
two enterotoxins are the leading causes of children's diarrhea and travelers' diarrhea …

A chimeric protein-based vaccine elicits a strong IgG antibody response and confers partial protection against Shiga toxin-producing Escherichia coli in mice

DA Montero, R Garcia-Betancourt, RM Vidal… - Frontiers in …, 2023 - frontiersin.org
Background Shiga toxin-producing Escherichia coli (STEC) is a foodborne pathogen that
causes gastrointestinal infections, ranging from acute diarrhea and dysentery to life …