Therapeutic angiogenesis/vasculogenesis represents a new approach to treating patients
with ischemic disease not curable with conventional treatment. Manipulation of the …

Angiogenesis provides a mechanism by which delivery of oxygen and nutrients is adapted
to compliment changes in tissue mass or metabolic activity. However, maladaptive …

The pathogenesis of diabetic nephropathy remains poorly defined, and animal models that
represent the human disease have been lacking. It was demonstrated recently that the …

Stroke-induced neurological deficits and mortality are often associated with timing of
treatment after the onset of stroke. We showed that local delivery of the human tissue …

Over the past two decades, extensive research has focused on arterial remodelling in both
physiological and pathological ageing. The concept now describes the growth as well as the …

Diabetes mellitus increases the risk and accelerates the course of peripheral artery disease,
making patients more susceptible to ischemic events and infections and delaying tissue …

Aims/hypothesis Benfotiamine, a vitamin B1 analogue, reportedly prevents diabetic
microangiopathy. The aim of this study was to evaluate whether benfotiamine is of benefit in …

Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal
damage. Background Chronic renal disease is associated with oxidative stress and reduced …

Reduced migratory function of circulating angiogenic progenitor cells (CPCs) has been
associated with impaired neovascularization in patients with cardiovascular disease (CVD) …

The pathogenesis of arterial hypertension often involves a rise in systemic vascular
resistance (vasoconstriction and vascular remodeling) and impairment of salt excretion in …