Almost 30 years ago it was first appreciated that anti-apoptotic B-cell lymphoma-2 (BCL-2)
prevents the induction of apoptosis not only in malignant cells, but also in normal cellular …

Physical exercise can convey a protective effect against cognitive decline in ageing and
Alzheimer's disease. While the long-term health-promoting and protective effects of exercise …

It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical
antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase …

Caspase-3, onto which there is a convergence of the intrinsic and extrinsic apoptotic
pathways, is the main executioner of apoptosis. We here review the current literature on the …

Programmed cell death (PCD) is an evolutionarily conserved contributor to nervous system
development. In the vertebrate peripheral nervous system, PCD is the basis of the …

Many signaling pathways participate in both synaptic plasticity and neuronal degeneration.
While calpains participate in these phenomena, very few studies have evaluated the …

Sensory axons degenerate following separation from their cell body, but partial injury to
peripheral nerves may leave the integrity of damaged axons preserved. We show that an …

Microglial cells are the resident tissue macrophages of the CNS and are widely recognized
for their immune surveillance of the healthy CNS. In addition to this well-accepted function …

The nerve growth factor family of growth factors, collectively known as neurotrophins, are
evolutionarily ancient regulators with an enormous range of biological functions. Reflecting …

In the last decade, tremendous progress has been made in understanding the biology of
microglia–ie the fascinating immigrated resident immune cell population of the central …