Daptomycin is a cyclic lipopeptide antibiotic, which was discovered in 1987 and entered the
market in 2003. To date, it serves as last resort antibiotic to treat complicated skin infections …

Antibiotics that use novel mechanisms are needed to combat antimicrobial resistance,–.
Teixobactin represents a new class of antibiotics with a unique chemical scaffold and lack of …

We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

Nisin inhibits bacterial growth by generating pores in cell membrane and interrupting cell-
wall biosynthesis through specific lipid II interaction. However, the role of the hinge region …

Molecular dynamics (MD) simulation is a useful technique to study the interaction between
molecules and how they are affected by various processes and processing conditions. This …

The antimicrobial peptide nisin exerts its activity by a unique dual mechanism. It permeates
the cell membranes of Gram-positive bacteria by binding to the cell wall precursor Lipid II …

Resistance to antibiotics has posed a high demand for novel strategies to fight bacterial
infections. Antimicrobial peptides (AMPs) are a promising alternative to conventional …

In response to the growing threat posed by antibiotic-resistant bacterial strains, extensive
research is currently focused on developing antimicrobial agents that target lipid II, a vital …

Antibiotics (AB) resistance is a major threat to global health, thus the development of novel
AB classes is urgently needed. Lantibiotics (ie nisin) are natural compounds that effectively …

The increasing rates of resistance among bacteria and to a lesser extent fungi have resulted
in an urgent need to find new molecules that hold therapeutic promise against multidrug …