Pharmacotherapeutics applications and chemistry of chalcone derivatives
Chalcones have been well examined in the extant literature and demonstrated antibacterial,
antifungal, anti-inflammatory, and anticancer properties. A detailed evaluation of the …
antifungal, anti-inflammatory, and anticancer properties. A detailed evaluation of the …
Chalcone scaffolds as anticancer drugs: a review on molecular insight in action of mechanisms and anticancer properties
Cancer is the deadliest disease worldwide and the development of safer chemical entities to
treat cancer is one of the major challenges of medicinal chemistry. The emergence of new …
treat cancer is one of the major challenges of medicinal chemistry. The emergence of new …
Enantioselective oxidative multi-functionalization of terminal alkynes with nitrones and alcohols for expeditious assembly of chiral α-alkoxy-β-amino-ketones
S Zhou, Y Li, X Liu, W Hu, Z Ke… - Journal of the American …, 2021 - ACS Publications
Catalytic oxidative functionalization of alkynes has emerged as an effective method in
synthetic chemistry in recent decades. However, enantioselective transformations via metal …
synthetic chemistry in recent decades. However, enantioselective transformations via metal …
Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: synthesis, characterization and anticancer activity
Cancer treatment still requires new compounds to be discovered. Chalcone and its
derivatives exhibit anticancer potential in different cancer cells. A new series of benzofuran …
derivatives exhibit anticancer potential in different cancer cells. A new series of benzofuran …
Synthesis, molecular docking, and in-vitro studies of pyrimidine-2-thione derivatives as antineoplastic agents via potential RAS/PI3K/Akt/JNK inhibition in breast …
In the present investigation, derivatives from (2–6) containing pyrimidine-2-thione moiety
incorporated with different heterocycles such as pyrazoline, phenyl pyrazoline, and …
incorporated with different heterocycles such as pyrazoline, phenyl pyrazoline, and …
The behavior of some chalcones on acetylcholinesterase and carbonic anhydrase activity
Carbonic anhydrase (CA) has a key role in respiration, carbon dioxide and bicarbonate
transport. Acetylcholinesterase (AChE) is a serine hydrolase and mostly abundant at …
transport. Acetylcholinesterase (AChE) is a serine hydrolase and mostly abundant at …
Recent Advances and Developments of in vitro Evaluation of Heterocyclic Moieties on Cancer Cell Lines
Besides worthy development in cancer therapy, cancer is still one of the leading causes of
death, worldwide. The future burden of cancer will probably be even larger because people …
death, worldwide. The future burden of cancer will probably be even larger because people …
Synthesis of Chalcone Derivatives: Inducing Apoptosis of HepG2 Cells via Regulating Reactive Oxygen Species and Mitochondrial Pathway
H Zhu, L Tang, C Zhang, B Wei, P Yang, D He… - Frontiers in …, 2019 - frontiersin.org
Chalcone derivatives, as a hot research field, exhibit a variety of physiological bioactivities
and target multiple biological receptors. Based on the skeleton of (E)-1, 3-diphenyl-2 …
and target multiple biological receptors. Based on the skeleton of (E)-1, 3-diphenyl-2 …
Developing new hybrid scaffold for urease inhibition based on carbazole-chalcone conjugates: Synthesis, assessment of therapeutic potential and computational …
Although a diverse range of chemical entities offering striking therapeutic potential against
urease enzyme has been reported, the key challenges (toxicity and safety) associated with …
urease enzyme has been reported, the key challenges (toxicity and safety) associated with …
One‐pot and two‐pot methods for chalcone derived pyrimidines synthesis and applications
Chalcone‐derived pyrimidine is a well‐known heterocyclic compound that is commonly
present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio‐isosteres …
present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio‐isosteres …