Recent developments in chimeric NSAIDs as safer anti‐inflammatory agents

SK Suthar, M Sharma - Medicinal research reviews, 2015 - Wiley Online Library
NSAIDs are among the most widely prescribed medications across the world, but the
gastrointestinal (GI) toxicity still remains the biggest problem and the challenge for current …

Mutual Prodrugs-Codrugs

A Nudelman - Current Medicinal Chemistry, 2023 - ingentaconnect.com
This review encapsulates an extensive variety of substances identified as mutual prodrugs
or codrugs, wherein two, or sometimes three, biologically active moieties are linked using an …

[PDF][PDF] Molecular docking studies and evaluation of the anti-inflammatory activity of ibuprofen-tranexamic acid codrug

TH Mousa, ZMJ Al-Obaidi… - Latin American Journal of …, 2021 - researchgate.net
The recent work searches the pharmacological activity of the new Ibuprofen-tranexamic acid
codrug as an active anti-inflammatory drug and compares with a standard, ibuprofen drug …

[PDF][PDF] Synthesis, characterization and evaluation of prodrugs of ciprofloxacin clubbed with benzothiazoles through N-Mannich base approach

M Piplani, AC Rana, PC Sharma - Chem. Biol. Lett, 2016 - academia.edu
The present study aims towards the design and synthesis of N-Mannich base prodrugs of
ciprofloxacin with benzothiazoles to improve the therapeutic potential of antibacterial agent …

Synthesis and Quantitative Analysis of Diastereomeric Linked Ester Conjugates With Remote Stereocenters Using High‐Field NMR and Chiral HPLC

E Doyle, J Parve, M Kudryashova, S Tamp… - Chirality, 2013 - Wiley Online Library
ABSTRACT A stereochemically safe high‐yielding procedure for linking unprotected as well
as protected hydroxycarboxylic acids to chiral secondary alcohols via glycolic acid linker is …

[HTML][HTML] Pharmacological screening of anti-arthritic effect of biological synthesis znonps by Syzygium aromaticum in rats

RM Ahmad, OMS Ibrahim - Adv. Anim. Vet. Sci, 2023 - researcherslinks.com
The study was conducted to synthesize zinc oxide nanoparticles (ZnONPs) biologically by
using Syzagium aromaticam extract and evaluate the effect against Polyarthritis produced by …

[PDF][PDF] Enhancing Gastrointestinal Tolerance-The Promise of Mutual Prodrugs in NSAID Therapy: A Review

P Jayshree, C Harsh, M Arshiya, G Chandan, S Misba - researchgate.net
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely employed for managing pain and
inflammation, but their use is associated with significant gastrointestinal adverse effects …

[PDF][PDF] Synthesis & Chemical Hydrolysis Study of some NSAIDs Linked to Natural Antioxidant via Alanine

MF Mahdi, AH Dawood, HAM Jawed… - Journal: Journal of …, 2013 - researchgate.net
Some of non-steroidal anti-inflammatory drugs (NSAIDs); have been coupled to antioxidant
(thymolor menthol) via alanine amino acid spacer which has anti-inflammatory …

[引用][C] Synthesis, pharmacological activity and hydrolytic behaviour of mutual prodrugs of ibuprofen

S Nanda, DP Pathak - International …, 2014 - International Journal of …