Environmental immune disruptors, inflammation and cancer risk

PA Thompson, M Khatami, CJ Baglole, J Sun… - …, 2015 - academic.oup.com
An emerging area in environmental toxicology is the role that chemicals and chemical
mixtures have on the cells of the human immune system. This is an important area of …

Antioxidants in mitigating phthalate-induced male reproductive toxicity: A comprehensive review

S Mondal, A Bandyopadhyay - Chemosphere, 2024 - Elsevier
Phthalates, widely used as plasticizers, have been increasingly linked to male reproductive
toxicity through mechanisms including oxidative stress, endocrine disruption, inflammation …

Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro

LM Tetz, AA Cheng, CS Korte, RW Giese… - Toxicology and applied …, 2013 - Elsevier
Di-2-ethylhexyl phthalate (DEHP) is an environmental contaminant commonly used as a
plasticizer in polyvinyl chloride products. Exposure to DEHP has been linked to adverse …

Multiple transcriptomic profiling: p53 signaling pathway is involved in DEHP-induced prepubertal testicular injury via promoting cell apoptosis and inhibiting cell …

J Wang, T Zhao, J Chen, L Kang, Y Wei, Y Wu… - Journal of hazardous …, 2021 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a widely-used plasticizer and has long been
recognized as an endocrine-disrupting chemical with male reproductive toxicities. DEHP …

Fetal origin of endocrine dysfunction in the adult: the phthalate model

DB Martinez-Arguelles, E Campioli, M Culty… - The Journal of steroid …, 2013 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer with endocrine disrupting
properties that is found ubiquitously in the environment as well as in human amniotic fluid …

The effect of di-2-ethylhexyl phthalate on inflammation and lipid metabolic disorder in rats

L Zhou, H Chen, Q Xu, X Han, Y Zhao, X Song… - Ecotoxicology and …, 2019 - Elsevier
Background Plasticizer di-2-ethylhexyl phthalate (DEHP) can induce lipid metabolic
disorder. There was a chronic low level inflammatory response in adipose tissue of patients …

p53-dependent apoptosis contributes to di-(2-ethylhexyl) phthalate-induced hepatotoxicity

M Ha, L Wei, X Guan, L Li, C Liu - Environmental Pollution, 2016 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP) is used extensively in many personal care and
consumer products, resulting in widespread non-occupational human exposure through …

Environmentally relevant concentrations of di (2-ethylhexyl) phthalate exposure alter larval growth and locomotion in medaka fish via multiple pathways

WK Yang, LF Chiang, SW Tan, PJ Chen - Science of The Total Environment, 2018 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer, with evidence of
ubiquitous human exposure and widespread occurrence in the aquatic environment. It is an …

Genotoxicity of phthalates

P Erkekoglu, B Kocer-Gumusel - Toxicology Mechanisms and …, 2014 - Taylor & Francis
Many of the environmental, occupational and industrial chemicals are able to generate
reactive oxygen species (ROS) and cause oxidative stress. ROS may lead to genotoxicity …

The long-term DEHP exposure confers multidrug resistance of triple-negative breast cancer cells through ABC transporters and intracellular ROS

M Jadhao, EM Tsai, HC Yang, YF Chen, SS Liang… - Antioxidants, 2021 - mdpi.com
The characteristics of phthalates had been thought to be similar to endocrine disruptors,
which increases cancer risk. The role of phthalates in acquired drug resistance remains …