Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant
and its potential as a serious environmental health threat is beginning to be recognized …

Free radical formation and oxidative damage have been extensively investigated and
validated as important contributors to the pathophysiology of acute central nervous system …

Free radical-induced oxidative damage reactions, and membrane lipid peroxidation (LP), in
particular, are among the best validated secondary injury mechanisms in preclinical …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Multiple sclerosis (MS) is a multifactorial disease of the central nervous system (CNS)
characterized by an inflammatory process and demyelination. The etiology of the disease is …

Secondary injury is a term applied to the destructive and self-propagating biological
changes in cells and tissues that lead to their dysfunction or death over hours to weeks after …

One of the most investigated molecular mechanisms involved in the secondary
pathophysiology of acute spinal cord injury (SCI) is free radical-induced, iron-catalyzed lipid …

Extensive evidence has demonstrated an important role of oxygen radical formation (ie,
oxidative stress) as a mediator of the secondary injury process that occurs following primary …

Spinal cord injury (SCI) is a serious problem in the central nervous system resulting in high
disability and mortality with complex pathophysiological mechanisms. Oxidative stress is …

Significance: Traumatic spinal cord injury (SCI) causes significant disruption to neuronal,
glial, vascular, and extracellular elements. The spinal cord extracellular matrix (ECM) …