The genome of mammalian sperm is largely packaged by sperm-specific proteins termed
protamines. The presence of some residual nucleosomes has, however, emerged as a …

Background The concept of the inheritance of acquired traits, a foundational principle of
Lamarck's evolutionary theory, has garnered renewed attention in recent years. Evidence for …

Sperm chromatin retains small amounts of histones, and chromatin states of sperm mirror
gene expression programs of the next generation. However, it remains largely unknown how …

Paternal chromatin undergoes extensive structural and epigenetic changes during
mammalian spermatogenesis, producing sperm with an epigenome optimized for the …

Round spermatid injection (ROSI) is the last resort and recourse for men with nonobstructive
azoospermia to become biological fathers of their children. However, the ROSI-derived …

Highlights•Epigenome regulating gene expression programs underlies male germ cell
identity and spermatogenesis.•Epigenetic priming ensure the maintenance of male germ …

The hypothalamus in the brain plays a pivotal role in controlling energy balance in
vertebrates. Nutritional excess through high‐fat diet (HFD) feeding can dysregulate …

Round spermatid injection (ROSI), one of the assistant reproductive technologies, was used
to treat partial infertility patients suffering from non-obstructive azoospermia. However, the …

Mouse cloning by nuclear transfer using freeze-drying (FD) somatic cells is now possible,
but the success rate is significantly lower than that of FD spermatozoa. Because …

The challenges posed by climate change and increasing world population are stimulating
renewed efforts for improving the sustainability of animal production. To meet such …