▪ Abstract While still incomplete, the first data concerning the biochemistry of T cell receptor–
ligand interactions in cell-free systems seem to have considerable predictive value …

▪ Abstract Over the past decade, key protein interactions contributing to T cell antigen
recognition have been characterized in molecular detail. These have included interactions …

CD8+ T lymphocytes recognize antigens as short peptides bound to MHC class I molecules.
Available methods cannot determine the number and distribution of these ligands on …

Abstract DEVELOPMENT of thymocytes involves two distinct outcomes resulting from
superficially similar events. Recognition by thymocytes of major histocompatibility complex …

The relative roles of CD8, TCR: pepMHC affinity, and TCR: pepMHC dissociation rate in T
cell activation have remained controversial. To determine the relationships among these …

Abstract THE TGF-β/activin/BMP cytokine family signals through serine/threonine kinase
receptors, but how the receptors transduce the signal is unknown. The Mad (Mothers against …

Cell-based antitumor immunity is driven by CD8+ cytotoxic T cells bearing TCR that
recognize specific tumor-associated peptides bound to class I MHC molecules. Of several …

▪ Abstract T cells constantly sample their environment using receptors (TCR) that possess
both a germline-encoded low affinity for major histocompatibility complex (MHC) molecules …

T cell receptor (TCR) binding to diverse peptide-major histocompatibility complex (pMHC)
ligands results in various degrees of T cell activation. Here we analyze which binding …

T cell receptors (TCRs) exhibit genetic and structural diversity similar to antibodies, but they
have binding affinities that are several orders of magnitude lower. It has been suggested that …