Alkoxy Exchange Strategy for the Synthesis of N,N′-Dimethylated (Alkoxy)triazinediones as Solid Reagents for Acid-Catalyzed O-Alkylation

H Fujita, T Yagitani, M Kunishima - The Journal of Organic …, 2024 - ACS Publications
N, N′-Dimethylated (alkoxy) triazinediones (DMATs-R) with eight different O-alkyl groups
(R), such as benzyl, allyl, and tert-butyl groups, were synthesized in 61–94% yield through …

Development of triazinone-based condensing reagents for amide formation

K Yamada, M Kota, K Takahashi, H Fujita… - The Journal of …, 2019 - ACS Publications
Novel triazinone-based condensing reagents have been developed. The palladium-
catalyzed O–N allylic rearrangement of 2-(allyloxy)-4, 6-dichloro-1, 3, 5-triazine and …

[HTML][HTML] Development of a method for the synthesis of 2, 4, 5-trisubstituted oxazoles composed of carboxylic acid, amino acid, and boronic acid

K Yamada, N Kamimura… - Beilstein Journal of …, 2017 - beilstein-journals.org
A novel method for the synthesis of trisubstituted oxazoles via a one-pot oxazole
synthesis/Suzuki–Miyaura coupling sequence has been developed. One-pot formation of 5 …

Triazine-Based Cationic Leaving Group: Synergistic Driving Forces for Rapid Formation of Carbocation Species

H Fujita, S Kakuyama, S Fukuyoshi… - The Journal of …, 2018 - ACS Publications
A new triazine-based cationic leaving group has been developed for the acid-catalyzed
alkylation of O-and C-nucleophiles. There are two synergistic driving forces, namely, stable …

Development of a Purely Isolable (Dimorpholino) triazine-Based Reagent for the Epoxidation of Alkenes

H Fujita, T Kato, T Betsuyaku, M Kunishima - Synlett, 2024 - thieme-connect.com
A triazine-based reagent, 2-hydroperoxy-4, 6-dimorpholino-1, 3, 5-triazine (Triazox-II), was
developed for alkene epoxidation. This reagent can be prepared from inexpensive starting …

Development of triazine-based benzylating reagents possessing t-butyl group on the triazine core: thermally controllable reagents for the initiation of reaction

Y Karuo, K Yamada, M Kunishima - Chemical and Pharmaceutical …, 2018 - jstage.jst.go.jp
Abstract Benzylating reagents, 4-(4, 6-di-t-butyl-1, 3, 5-triazin-2-yl)-4-benzylmorpholinium
triflate, and related derivatives have been developed. The reagents release benzyl triflate as …

Preparation of Alkyl Ethers with Diallyltriazinedione‐Type Alkylating Agents (ATTACKs‐R) Under Acid Catalysis

H Fujita, R Yamashita, T Fujii, K Yamada… - European Journal of …, 2019 - Wiley Online Library
Diallyltriazinedione‐type acid‐catalyzed alkylating agents (ATTACKs‐R) with 10 different
alkyl groups (R), including benzyl, substituted benzyl, allyl, and methyl groups were …

Triazines, Tetrazines, and Fused Ring Polyaza Systems

P Audebert, C Allain - Progress in Heterocyclic Chemistry, 2018 - Elsevier
A yearly account of research in molecular chemistry of high-nitrogen content aromatic
heterocycles is provided. Specific accent has been put on triazines and tetrazines, by far the …

Expanding the structural diversity of discrete polymers accessible through iterative exponential growth

K Khokhlov - 2023 - dspace.mit.edu
Iterative exponential growth is a powerful method for the synthesis of atomically defined
macromolecules. However, preparation of enantiopure IEG-ready monomers can be …

Cooperation of the Neutral and the Cationic Leaving Group Pathways in Acid-Catalyzed O-Benzylation of TriBOT

H Fujita, N Hayakawa, M Kunishima - The Journal of Organic …, 2018 - ACS Publications
The reaction profile of acid-catalyzed O-benzylation with 2, 4, 6-tris (benzyloxy)-1, 3, 5-
triazine (TriBOT) was analyzed to study the reaction kinetics. The first-order kinetic constant …