Chronic kidney disease (CKD) is a progressive disease that affects millions of adults every
year. Major risk factors include diabetes, hypertension, and obesity, which affect millions of …

Patients with chronic kidney disease (CKD) are at an increased cardiovascular risk
compared with the general population, which is driven, at least in part, by mechanisms that …

Background Cisplatin is an effective chemotherapeutic drug, but it may induce both acute
and chronic kidney problems. The pathogenesis of chronic kidney disease (CKD) …

Background: T-cell death-associated gene 51 (TDAG51) belongs to the transcription factor
family and is involved in the energy homeostasis of the liver through the regulation of …

Context Persistent hyperglycaemia increases SET7/9 expression and endoplasmic
reticulum (ER) stress which causes inflammation, apoptosis, and fibrosis in renal tubular …

Balancing microglia M1/M2 polarization is an effective therapeutic strategy for
neuroinflammation after subarachnoid hemorrhage (SAH). Pleckstrin homology-like domain …

Studies have confirmed that elevated glucose levels could lead to renal fibrosis through the
process of ferroptosis. Liraglutide, a human glucagon-like peptide-1 (GLP-1) analogue, is a …

Mitochondrial dysfunction and endoplasmic reticulum (ER) stress occur in ischemic stroke.
The disruption of these two organelles can directly lead to cell death through various …

Endoplasmic reticulum stress is associated with insulin resistance and the development of
nonalcoholic fatty liver disease. Deficiency of the endoplasmic reticulum stress response T …

Pleckstrin homology-like domain, family A, member 1 (PHLDA1), one of the three members
of PHLDA (1–3) family, has been reported to be expressed in mammalian cells and tissues …