In pathophysiology, reactive oxygen species control diverse cellular phenotypes by
oxidizing biomolecules. Among these, the guanine base in nucleic acids is the most …

Bacteria have to cope with oxidative stress caused by distinct Reactive Oxygen Species
(ROS), derived not only from normal aerobic metabolism but also from oxidants present in …

Since the introduction of the central dogma of molecular biology in 1958, various RNA
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …

Type 2 diabetes is a redox disease. Oxidative stress and chronic inflammation induce a
switch of metabolic homeostatic set points, leading to glucose intolerance. Several diabetes …

RNA modifications are important regulatory elements of RNA functions. However, most
genome-wide mapping of RNA modifications has focused on messenger RNAs and transfer …

Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

The CXC chemokine receptor 4 (CXCR4) in endothelial cells (ECs) and vascular smooth
muscle cells (VSMCs) is crucial for vascular integrity. The atheroprotective functions of …

Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs)
inadequately recapitulate complete development and result in PSC-derived cardiomyocytes …

Oxidative stress contributes to tumourigenesis by altering gene expression. One
accompanying modification, 8-oxoguanine (o8G) can change RNA–RNA interactions via …

Gastric cancer (GC) was the fourth deadliest cancer in the world in 2020, and about 770,000
people died from GC that year. The death of patients with GC is mainly caused by the …