Molecular mechanisms of myocardial remodeling
B Swynghedauw - Physiological reviews, 1999 - journals.physiology.org
Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …
Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways
C Ruwhof, A van der Laarse - Cardiovascular research, 2000 - academic.oup.com
Cardiac hypertrophy is a well known response to increased hemodynamic load. Mechanical
stress is considered to be the trigger inducing a growth response in the overloaded …
stress is considered to be the trigger inducing a growth response in the overloaded …
Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure. Marked upregulation of genes encoding extracellular matrix …
MO Boluyt, L O'Neill, AL Meredith, OH Bing… - Circulation …, 1994 - Am Heart Assoc
The failing heart is characterized by impaired cardiac muscle function and increased
interstitial fibrosis. Our purpose was to determine whether the functional impairment of the …
interstitial fibrosis. Our purpose was to determine whether the functional impairment of the …
Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding.
AM Feldman, EO Weinberg, PE Ray… - Circulation research, 1993 - Am Heart Assoc
Left ventricular hypertrophy (LVH) is associated with reinduction of the fetal program of gene
expression. It is unclear whether this pattern of cardiac gene expression changes with the …
expression. It is unclear whether this pattern of cardiac gene expression changes with the …
Structural remodeling and mechanical dysfunction of cardiac myocytes in heart failure
AM Gerdes, JM Capasso - Journal of molecular and cellular cardiology, 1995 - Elsevier
End stage heart failure due to ischemic (ICM) or dilated (DCM) cardiomyopathy is
characterized by a dilated, relatively thin-walled ventricle. The hypothesis has been …
characterized by a dilated, relatively thin-walled ventricle. The hypothesis has been …
Gender differences in molecular remodeling in pressure overload hypertrophy
EO Weinberg, CD Thienelt, SE Katz, J Bartunek… - Journal of the American …, 1999 - jacc.org
OBJECTIVES The objective of this study was to examine gender differences in left
ventricular (LV) function and expression of cardiac genes in response to LV pressure …
ventricular (LV) function and expression of cardiac genes in response to LV pressure …
Expression of A-, B-, and C-type natriuretic peptide genes in failing and developing human ventricles. Correlation with expression of the Ca (2+)-ATPase gene.
T Takahashi, PD Allen, S Izumo - Circulation research, 1992 - Am Heart Assoc
Brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are novel natriuretic
peptides, originally isolated from porcine brain. Similar to atrial natriuretic peptide (ANP) …
peptides, originally isolated from porcine brain. Similar to atrial natriuretic peptide (ANP) …
Angiotensin receptor regulates cardiac hypertrophy and transforming growth factor-beta 1 expression.
AD Everett, A Tufro-McReddie, A Fisher, RA Gomez - Hypertension, 1994 - Am Heart Assoc
The role of angiotensin II via the angiotensin type 1 or type 2 receptor in the development of
cardiac hypertrophy was determined in adult male Sprague-Dawley rats subjected to …
cardiac hypertrophy was determined in adult male Sprague-Dawley rats subjected to …
Activation of nuclear factor-κB is necessary for myotrophin-induced cardiac hypertrophy
S Gupta, NH Purcell, A Lin, S Sen - The Journal of cell biology, 2002 - rupress.org
The transcription factor nuclear factor-κB (NF-κB) regulates expression of a variety of genes
involved in immune responses, inflammation, proliferation, and programmed cell death …
involved in immune responses, inflammation, proliferation, and programmed cell death …
Age-related differences in the expression of proto-oncogene and contractile protein genes in response to pressure overload in the rat myocardium.
T Takahashi, H Schunkert, S Isoyama… - The Journal of …, 1992 - Am Soc Clin Investig
Cardiac adaptation to hemodynamic stress involves both quantitative (hypertrophy) and
qualitative (pattern of gene expression) changes. Our previous studies have shown that …
qualitative (pattern of gene expression) changes. Our previous studies have shown that …