Being overweight or obese, as measured with body-mass index or central adiposity (waist
circumference), and the trajectory of body-mass index over the life course have been …

Plasminogen activator inhibitor 1 (PAI-1) is a member of the serine protease inhibitor
(serpin) superfamily. PAI-1 is the principal inhibitor of the plasminogen activators, tissue …

Adipocytes store triglyceride during periods of nutritional affluence and release free fatty
acids during fasting through coordinated cycles of lipogenesis and lipolysis. While much is …

This study identifies monocyte chemoattractant protein 1 (MCP-1) as an insulin-responsive
gene. It also shows that insulin induces substantial expression and secretion of MCP-1 both …

Obesity is associated with an increased incidence of insulin resistance (IR), type 2 diabetes
mellitus and cardiovascular diseases. The increased risk for cardiovascular diseases could …

Type 2 diabetes is associated with altered immune and hemostatic responses. We
investigated the selective effects of hyperglycemia and hyperinsulinemia on innate immune …

The adipose tissue has become a central focus in the pathogenesis of obesity-mediated
cardiovascular and metabolic disease. Here we demonstrate that adipose sphingolipid …

Although plasminogen activator inhibitor 1 (PAI-1) is one of the primary regulators of the
fibrinolytic system, it also has dramatic effects on cell adhesion, detachment and migration …

The metabolic syndrome is characterized by a combination of obesity, chronic inflammation
and insulin resistance. This syndrome also has features of a hypercoagulable state …

Abnormalities in coagulation and haemostasis represent a well-known link between obesity
and thrombosis (both arterial and venous). Several studies have shown that obese patients …